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New insights into RTS,S efficacy and immune response in children

New insights into RTS,S efficacy and immune response in children
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Comunidad Autonoma De Cataluna , Universidade Eduardo Mondlane , James Beeson , Paul Gilson , Gaoqian Feng , University Of Barcelona , University Of Melbourne , Vaccines Laboratory , World Health Organization , Burnet Institute , Professor James Beeson , Malaria Immunity , Centro De Investiga , Faculdade De Medicina , How Science Matters , Show Science ,

Neighbors' use of water and sanitation facilities can affect children's health: a cohort study in Mozambique using a spatial approach | BMC Public Health

Impact evaluation of most water, sanitation and hygiene (WASH) interventions in health are user-centered. However, recent research discussed WASH herd protection – community WASH coverage could protect neighboring households. We evaluated the effect of water and sanitation used in the household and by household neighbors in children’s morbidity and mortality using recorded health data. We conducted a retrospective cohort including 61,333 children from a district in Mozambique during 2012–2015. We obtained water and sanitation household data and morbidity data from Manhiça Health Research Centre surveillance system. To evaluate herd protection, we estimated the density of household neighbors with improved facilities using a Kernel Density Estimator. We fitted negative binomial adjusted regression models to assess the minimum children-based incidence rates for every morbidity indicator, and Cox regression models for mortality. Household use of unimproved water and ....

United States , Monitoring Program , R Statistical Software Version , Southern Mozambique , Centro De Investiga , District Hospital , Children Years , Kernel Density Estimator ,