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Frontiers | An Update on Protective Effectiveness of Immune Responses After Recovery From COVID-19

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) exhibits variable immunity responses among hosts based on symptom severity. Whether immunity in recovered individuals is effective for avoiding reinfection is poorly understood. Determination of immune memory status against SARS-CoV-2 helps identify reinfection risk and vaccine efficacy. Hence, after recovery from COVID-19, evaluation of protective effectiveness and durable immunity of prior disease could be significant. Recent reports described the dynamics of SARS-CoV-2 -specific humoral and cellular responses for more than six months in convalescent SARS-CoV-2 individuals. Given the current evidence, NK cell subpopulations, especially the memory-like NK cell subset, indicate a significant role in determining COVID-19 severity. Still, the information on the long-term NK cell immunity conferred by SARS-CoV-2 infection is scant. The evidence from vaccine clinical trials and observational studies indicates that hybrid natural/ ....

Eastern Cape , South Africa , Western Cape , Saudi Arabia , United Kingdom , South Korea , Free State , Yunbao Pan , Paige Lawrence , Zhengm Tim , Cohen Tervaert , Cullym Exosome , Jernbom Falk , Nasrin Shokrpour , Shiraz University Of Medical Science , Health Sci , Terminal Differentiation Of Plasma Cells In Health , Shiraz University Of Medical Sciences , Development Of Clinical Research Nemazee Hospital , S Specific Igg , Natural Immunity , Vaccine Immunity , Shiraz University , Medical Science , Medical Sciences , Clinical Research ,

Frontiers | Case Report: Delayed Onset Multi-Organ Toxicities in a Melanoma Patient Achieving Complete Response to BRAF/MEK Inhibition

Autoimmune toxicities, while common following treatment with cancer immunotherapies, are not well-characterized in patients treated with BRAF/MEK inhibitors. Emerging data suggest that autoimmune effects may be linked with superior responses to both treatment modalities; however, there is little evidence describing mechanisms of immune-related toxicity for patients on BRAF/MEK inhibitors. Here we describe the experience of a 59-year-old HLA-A2, A29, B27-positive male patient with recurrent/metastatic melanoma. After progression on checkpoint inhibitor therapy, he was treated with dabrafenib/trametinib followed by encorafenib/binimetinib, which were well-tolerated. 18 months into BRAF/MEK inhibitor therapy, he developed a series of sudden-onset, severe toxicities including bilateral panuveitis, cytopenias, joint pain, skin rash, hypercalcemia and interstitial nephritis, which led to BRAF/MEKi cessation. At that time, the patient was found to have a complete response, which is ongoing at ....

Chiarion Sileni , Yehs Vogt Koyanagi Harada , Brafi Meki , Homet Moreno , Dummerr Development Of Encorafenib , Uveitis Study Group , Emory University , University Of South Carolina , V Foundation Translational Award , Eve Technologies Corporation Alberta , Institutional Review Board At Emory University , Cytokine Profile , Institutional Review Board , Medical University , South Carolina , Human Discovery , Eve Technologies Corporation , Reve Technologies , Side Effects , Targeted Therapy , Med Abstract , Crossref Full Text , Melanoma With , New Englj Med , Mutated Advanced , Curr Opin Oncol ,

The A.30 Coronavirus Variant Warrants Closer Monitoring

The journal Cellular & Molecular Immunology published a peer-reviewed study on October 25, 2021, stating, 'COVID-19 vaccines that protect against severe disease and death are considered central to ending the pandemic.' However, the emergence of SARS-CoV-2 coronavirus variants with S protein mutations that confer resistance to neutralization might compromise COVID-19 vaccine efficacy. ....

Precision Vaccinations , Molecular Immunology , Open Access , Cell Mol Immunol ,