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DGAP-News: CatalYm GmbH: CatalYm to Present Initial Data of First-in-Human Trial of GDF-15 neutralizing antibody CTL-002 at the 2021 ASCO Annual Meeting


DGAP-News: CatalYm GmbH: CatalYm to Present Initial Data of First-in-Human Trial of GDF-15 neutralizing antibody CTL-002 at the 2021 ASCO Annual Meeting
The poster
A phase I, first-in-human clinical trial of the GDF-15 neutralizing antibody CTL-002 in subjects with advanced-stage solid tumors (ACRONYM: GDFATHER) , Abstract TPS2658
, will present CatalYm s first-in-human, two-part, open-label phase 1 clinical trial of CTL-002, a neutralizing antibody targeting GDF-15. GDF-15 is a factor that is secreted by several major tumor entities and interferes with effector T cell recruitment. In the GDFATHER-trial, patients with advanced-stage, solid tumors who have not responded or stopped responding to anti-PD-1/PD-L1 therapy are treated with CTL-002 as monotherapy and followed by combination with an anti-PD-1 antibody. The first patient was enrolled in December 2020. ....

United States , Christine Schuberth Wagner , Katja Arnold , Wachstumsfonds Bayern , Phil Lhuilier , Shaun Brown , Kostenloser Wertpapierhandel , Catalym Gmb , Phil Lhuillier , Joerg Wischhusen , Mc Services , European Union , European Fund For Strategic Investments , Novartis Venture Fund , Distribution Services , Catalym Gmbh , Present Initial Data , First In Human Trial , American Society , Clinical Oncology , Developmental Therapeutics , Eugen Leo , Chief Medical Officer , Chief Scientific Officer , Phill Huillier , Chief Executive Officer ,