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New drug reveals a key mechanism to overcome resistance to protein degraders

Protein degraders offer a novel approach to targeting undruggable diseases by hijacking the cell s degradation machinery.
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Comunidad Autonoma De Cataluna , Barbara Barbosa , Angewandte Chemie , Marko Cigler , Ferran Jos , Marta Vilaseca , Aikaterini Sfyaki , Mar Vilanova , Joan Pous , Sergi Rafael , Carles Perez Lopez , Cristina Mayor Ruiz , Antoni Riera , Mechanistic Elucidation , Marina Gay , Rotein Degraders Cells Degradation Undruggable Diseases , All Journal News , Alzheimers And Dementia , Drug Resistance , Parkinsons Disease , Fundació Institut De Recerca Biomèdica Irb Barcelona ,

39th Barcelona BioMed Conference focuses on latest advances in proximity induction-based pharmacology

Targeted protein degradation uses different types of "degrading" drugs (degraders) to force proximity between a target protein (for example, a mutated protein that contributes to the development of a disease) and the cellular machinery that directs protein degradation. ....

Comunidad Autonoma De Cataluna , Carles Perez Lopez , Aaaron Ciechanover , Avram Hershko , Megan Craig , Heidi Greulich , Jay Bradner , Alessio Ciuli , Irwin Rose , Miquel Duran Frigola , Patrick Aloy , Institute For Research , University Of Dundee , Broad Institute , Yale University , Cemm Research Center , Barcelona Biomed , Cristina Mayor Ruiz , Molecular Medicine , Targeted Protein Degradation , Drug Discovery , Nobel Prize ,

Targeted protein degradation as a therapeutic

This week, the Institute for Research in Biomedicine (IRB Barcelona) and the BBVA Foundation are hosting the 39th Barcelona BioMed Conference an event in which leading figures can exchange ideas and discuss the latest advances in the field of proximity induction-based pharmacology. The “Proximity-inducing pharmacology: Targeted protein degradation and beyond” conference, co-organised by Dr. Cristina Mayor-Ruiz, from IRB Barcelona, and Dr. Georg E. Winter, from the CeMM Research Center for Molecular Medicine in Vienna (Austria), is being held in Barcelona between 22 and 24 May. Dr. Mayor-Ruiz and Dr. Winter are experts in the development of "degraders". ....

Comunidad Autonoma De Cataluna , Miquel Duran Frigola , Avram Hershko , Heidi Greulich , Carles Perez Lopez , Irwin Rose , Alessio Ciuli , Patrick Aloy , Jay Bradner , Aaaron Ciechanover , Yale University , Institute For Research , Cemm Research Center , University Of Dundee , Broad Institute , Barcelona Biomed , Barcelona Biomed Conference , Cristina Mayor Ruiz , Molecular Medicine , Targeted Protein Degradation , Drug Discovery , Nobel Prize ,