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Chronic lymphocytic leukemia (CLL) has experienced a clinical revolution thanks to the discovery of crucial pathogenetic mechanisms. CLL is still an incurable disease due to intrinsic or acquired resistance of the leukemic clone. Venetoclax is a Bcl-2 inhibitor with a marked activity in CLL, but emerging patterns of resistance are being described. We hypothesize that intrinsic features of CLL cells may contribute to drive mechanisms of resistance to venetoclax. We analyzed the expression of IRF4, Notch2 and Mcl-1 in a cohort of CLL patients. We evaluated CLL cells viability after genetic and pharmaceutical modulation of Notch2 expression in patients harboring trisomy 12. We tested venetoclax in trisomy 12 CLL cells either silenced or not for Notch2 expression or in combination with an inhibitor of Mcl-1, AMG-176. Trisomy 12 CLL cells were characterized by low expression of IRF4 associated with high levels of Notch2 and Mcl-1. Notch2 and Mcl-1 expression determined protection of CLL cel ....
Role of carette or scott king is played by the dutch actress and singer patti fan defender. if it had been me i would probably have decided in favor of a singing career and not have married the baptist pastor better known as martin luther king. some cunt as martin luther king but that s me i didn t grow up as an afro-american woman in the sixty s i was. it s easy enough to say i would have done things differently maybe she didn t have the opportunity perhaps it was too dangerous to live certain dreams. martin luther king s political activism was certainly dangerous to his marriage and his family. for i was surprised by martin luther king s recklessness that at the age of 39 he got used to the idea of bomb attacks on his ....
We just do news stories on cabling and hope somebody picks it up. this is not arcane stuff. it s not complicated stuff or hard to find. this money truly is not wrapped up like christmas presents or stuffed into an nigerian spy chief s closet. donors to the inauguration did not actually pay for the inauguration. there was not $107 million worth of inauguration to pay for. if the police see you give somebody $200 on a street corner, and you re explanation when they ask you about that is you were buying a stick of gum or a loose carette of a guy, they re not going to believe you that that s what u gave him $200 for. and i know like big numbers are hard for me to get my head around. big numbers are hard to conceptize sometimes. if we take the unit has inaugurations, the inauguration ....