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Transformer-based large language models are making significant strides in various fields, such as natural language processing1–5, biology6,7, chemistry8–10 and computer programming11,12. Here, we show the development and capabilities of Coscientist, an artificial intelligence system driven by GPT-4 that autonomously designs, plans and performs complex experiments by incorporating large language models empowered by tools such as internet and documentation search, code execution and experimental automation. Coscientist showcases its potential for accelerating research across six diverse tasks, including the successful reaction optimization of palladium-catalysed cross-couplings, while exhibiting advanced capabilities for (semi-)autonomous experimental design and execution. Our findings demonstrate the versatility, efficacy and explainability of artificial intelligence systems like Coscientist in advancing research. Coscientist is an artificial intelligence system driven by GP

International conference on theory of information retrievalCurran associatesConference on researchEmerald cloud labDevelopment in information retrievalInternational symposium on machine programmingInternational conference on learning representationsNeural information processing systemsMachine programmingInternational conferenceLearning representationsHugging faceInformation retrievalMassive datasetsCambridge univBig data