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BBCNEWS Click October 3, 2021 11:51:00

It takes longer than you would think to fill a container with saliva. i ve only got to get it up to there. done! the problem is not this part. we can do this part quite well. the challenge is to find an area that is meaningful, and we have a lot of science behind it, so there is no consensus as to which dna areas we need to analyse, so company a may have their own genes that they believe are the most important ones and company b may have a different set of genes. we need to be able to communicate possibilities and probabilities to the public and that s not always an easy thing to do. even when scientists do agree on genes and their impact, more data is needed for a full picture. genetics can actually be quite meaningful if you combine it ....

Called Gedmatch , Dna Areas , Company B ,

BBCNEWS Click October 2, 2021 11:39:00

Was identified, with a mission to solve unsolvable cases. the company ceo david mittelman says the first step in the process is to clean up the dna, which is often degraded. in carla s case, it was more than 40 years old. the company then sequences that dna, looking at thousands of distinctive markers on the genome. in the traditional forensic dna testing framework, like for codas, there s about 20 of these positons in the dna that you re measuring, and that information can be used to confirm that you were at a crime scene or that someone closely related to you a sibling, parent or child, was at a crime scene. and that s the extent of what you can do with 20 markers. what we do at 0thram is we look at tens of thousands, to hundreds of thousands of markers, and with that information, we can detect more dista nt relationships. every time you test for dna, you lose a bit of the sample in the process. in carla s case there was little of the killer s dna left. it was likely this was ....

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BBCNEWS Click October 2, 2021 11:38:00

A crucial clue. most ancestry websites don t allow law enforcement checks but a few do. the website the police chose to use was a company called gedmatch. so effectively what they re doing is building family trees, - so you have to build back far enough till you reach what they call- a most recent common ancestor, i and then figure out where the trees came together and then. build forward from there. so by doing that, - you are able to zero in on who the potential suspect is. the capture of the golden state killer was a proof of concept moment, the technique worked, so could it be used to solve carla s case? you wanna find hits that are within third cousins, to make the case tractable, so we definitely had some within the third cousin range. 0thram was founded shortly after the golden state killer ....

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BBCNEWS Click October 2, 2021 11:48:00

What s the percentage balance, then, do you think between dna and lifestyle? i would say it s roughly 30 70. dna is around 30, lifestyle is around 70. dnanudge is not the only company in the dna nutrition and fitness space and many post kits home. neda gharani tried one after reacting to dairy and bread. once i did the test, i saw that i am actually lactose intolerant, which made sense, - and also i am at a slight increased risk for coeliac disease. just that knowledge that there . is an increased risk for me really helped me push me to that step of reducing the amount - of wheat that i eat. but neda, who is also a research scientist, raised red flags about simplified genetic reports. it s understandable for the general population, but maybe someone . who doesn t really understand genetics may take ....

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BBCNEWS Click October 2, 2021 14:39:00

The police had plenty of dna of the killer, however, it didn t match to any dna profiles in the fbi s database. 0ne enterprising officer decided to run the dna found at the murder scenes against dna collected by an ancestry website. these sites are usually designed for people to find genetic relatives through dna links but the police realised that if they put the killer s dna into the database they might be able to find the murderer s relatives, a crucial clue. most ancestry websites don t allow law enforcement checks but a few do. the website the police chose to use was a company called gedmatch. so effectively what they re doing is building family trees, - so you have to build back far enough till you reach what they call- a most recent common ancestor, i and then figure out where the trees came together and then. build forward from there. ....

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