It is 26 years since Orlando Pirates of South Africa lifted CA) silverware and a favourable draw has given them a good chance to end the drought this month.
The Soweto Buccaneers dodged the big guns in the quarter-finals, and face Al Ahly Tripoli of Libya in a semi-final first leg on Sunday believing they can overcome the north Africans on aggregate.
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Egyptian club Al Mokawloon Al Arab, who scored nine times at home in the CAF Confederation Cup preliminary round, could not manage a single goal in a last 32 first leg.
The Cairo club, back in pan-African competition after a 15-year absence, drew 0-0 with Tunisian visitors Etoile Sahel in a cagey clash in Cairo that produced few scoring chances.
Mokawloon lacked four regular starters due to Covid-19 and could have lost as Yassine Chikhaoui and Wajdi Kechrida of Etoile wasted the best opportunities.
Here, AFP Sport looks at five talking points from the 14 midweek first legs.
Mokawloon had a genuine penalty appeal rejected in a first leg showdown that promised much more than it delivered.