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Scientists uncover mutations that make cancer resistant to therapies targeting KRAS


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BOSTON - A gene called KRAS is one of the most commonly mutated genes in all human cancers, and targeted drugs that inhibit the protein expressed by mutated KRAS have shown promising results in clinical trials, with potential approvals by the U.S. Food and Drug Administration anticipated later this year. Unfortunately, cancer cells often develop additional mutations that make them resistant to such targeted drugs, resulting in disease relapse. Now researchers led by a team at Massachusetts General Hospital (MGH) have identified the first resistance mechanisms that may occur to these drugs and identified strategies to overcome them. The findings are published in ....

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Christmas Eve Storm: Hundreds still waiting for power in Philadelphia region


The Christmas Eve storm caused flooding, downed trees, and power outages across the Delaware and Lehigh valleys.
Our babysitter said, My dad has one if you want to come pick it up, and they live right in Springfield. So that s how we spent Christmas Day, said Tammy Gallagher.
The family says the lights went out very early Christmas morning, making for an unusual holiday on Dunwoody Drive.
It s been fun because it was different but I didn t like it when I couldn t see opening my presents, said Makayla Corcoran, age 11.
There s like nine houses on this side of the street, just total darkness, said Makayla s father, Brian Corcoran. I m just fortunate to have heat right now. ....

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