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Bone-Marrow-Derived Macrophages Promising for Preventing OA – The Horse


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Osteoarthritis (OA) commonly affects horses, yet available therapies have only limited effect on clinical signs and disease progression. In fact, some even block healing mechanisms. Bone-marrow-derived macrophages, a type of white blood cell that produce the anti-inflammatory mediator interleukin-10 (IL-10), however, show promise as a novel OA treatment approach, said Bruno Menarim, DVM, PhD, during his presentation at the 2020 American Association of Equine Practitioners’ Convention, held virtually.
Menarim, currently at the University of Kentucky’s Gluck Equine Research Center, in Lexington, reminded his audience that inflammation of the joint’s inner lining, or synovitis, is a hallmark of OA. In the face of acute inflammation, macrophages residing in the joint proliferate and recruit more macrophages from marrow of the long bones nearby to respond to injury. Among other activities, these macrophages (especially the bone marrow macrophages) produce IL ....

United States , Bruno Menarim , American Association Of Equine Practitioner Convention , University Of Kentucky Gluck Equine Research Center , Maryland College Of Veterinary Medicine , Equine Practitioner Convention , Gluck Equine Research Center , Virginia Maryland College , Veterinary Medicine , ஒன்றுபட்டது மாநிலங்களில் , அமெரிக்கன் சங்கம் ஆஃப் குதிரை ப்ர்யாக்டிஶநர் மாநாடு , பல்கலைக்கழகம் ஆஃப் கெந்‌டகீ க்லக் குதிரை ஆராய்ச்சி மையம் , மேரிலாந்து கல்லூரி ஆஃப் கால்நடை மருந்து , குதிரை ப்ர்யாக்டிஶநர் மாநாடு , க்லக் குதிரை ஆராய்ச்சி மையம் , வர்ஜீனியா மேரிலாந்து கல்லூரி , கால்நடை மருந்து ,