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Researchers identify over 2,000 genetic signa

Researchers led by Queen Mary University of London and supported by the National Institute for Health and Care Research (NIHR) have discovered over a hundred new regions of the human genome, also known as genomic loci, that appear to influence a person’s blood pressure. In total, over 2,000 independent genetic signals for blood pressure are now reported, demonstrating that blood pressure is a highly complex trait influenced by thousands of different genetic variants. ....

United Kingdom , United States , City Of , Markj Caulfield , Mikea Nall , Peter Vollenweider , Ruifang Li Gao , Helen Warren , Brucem Psaty , Johnn Danesh , Evangelos Evangelou , Tim Spector , Christopherj Odonnell , Patricia Munroe , Queen Mary University Of London , University Of Groningen , Scientific Advisory Committee For Sanofi , Metabolon Inc , High Throughput Science Omics Panel Member , Biomedical Research Centre , Metabolism Research , Veterans Administration , National Human Genome Research Institute , International Consortium For Blood Pressure , Vanderbilt University Medical Center , Method Of Research ,

Combining high quality data with rigorous methods: emulation of a target trial using electronic health records and a nested case-control design

Emulating a target trial reduces the potential for bias in observational comparative effectiveness research. Owing to feasibility constraints, large cohort studies often use electronic health records without validating key variables or collecting additional data. A case-control design allows researchers to validate, supplement, or collect additional data on key measurements in a much smaller sample compared with the entire cohort. In this article, Rasouli and colleagues describe methods to emulate a target trial using a nested case-control design, and provide a detailed guideline, an analytical program, and results of a clinical example.

#### Summary points

Randomized controlled trials are considered the ideal study design for comparative effectiveness research. Given that such trials are usually costly, lengthy, and, in some instances, unethical or infeasible, interest is increasing in using observational studies such as those conducted using data from electronic health ....

District Of Columbia , United States , Rogerw Logan , Miguela Hern , Matthew Nguyen , Kerril Wiggins , Brucem Psaty , Barbraa Dickerman , Kelly Meyers , Goodarz Danaei , Jessica Chubak , Bahareh Rasouli , Jamess Floyd , Kaiser Permanente , Kaiser Permanente Washington Health Research Institute , Novo Nordisk Foundation , Novo Nordisk Foundation No , Outcomes Research Institute , Vascular Health , Primary Prevention , Kaiser Permanente Washington , Public Health Research , Kaiser Permanente Washington Region , Kaiser Permanente Washington Health Research , Patient Centered Outcomes Research Institute ,

Heart attacks associated with faster cognitiv

In a recent study, a Johns Hopkins Medicine researcher and collaborators analyzed data on adults to determine if there is a link between having a heart attack and cognitive decline. ....

United States , Timothym Hughes , Stephen Sidney , Andrzej Galecki , Alden Gross , Michael Griswold , Ralphl Sacco , Mitchellsv Elkind , Kristine Yaffe , Jeremy Sussman , Andrewe Moran , Susan Heckbert , Dehua Han , Deboraha Levine , Brunoj Giordani , Alison Fohner , Brucem Psaty , Rachael Whitney , Michelle Johansen , Rebeccaf Gottesman , Emilym Brice , National Institute Of Neurological Disorders , Centers For Disease , Human Services , Department Of Health , National Institutes Of Health ,

Heart Attacks Tied to Quicker Cognitive Decline

Miragenews.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from miragenews.com Daily Mail and Mail on Sunday newspapers. ....

United States , Dehua Han , Timothym Hughes , Emilym Brice , Alden Gross , Brunoj Giordani , Kristine Yaffe , Ralphl Sacco , Andrewe Moran , Stephen Sidney , Michelle Johansen , Deboraha Levine , Michael Griswold , Mitchellsv Elkind , Jeremy Sussman , Brucem Psaty , Andrzej Galecki , Alison Fohner , Rebeccaf Gottesman , Susan Heckbert , Rachael Whitney , Centers For Disease , Human Services , National Institute Of Neurological Disorders , National Institutes Of Health , Department Of Health ,