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Meet the reviewers who have hit the jackpot selectscience.net - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from selectscience.net Daily Mail and Mail on Sunday newspapers.
22 Dec 2020 Many people with Alzheimer’s wake up frequently at night, nap excessively during the day, and lose their sense of time. Besides sleep cycles, the circadian clock also controls astrocyte and microglia activation, and knocking out one of the core clock genes, Bmal1, hastens plaque formation and promotes neuroinflammation and synaptic damage. Now, researchers led by Erik Musiek and Brian Lananna at Washington University in St. Louis report that Bmal1 regulates the gene for YKL-40, a marker of Alzheimer’s disease. Further, deleting the YKL-40 gene, Chi3l1, alters glial inflammatory responses, promotes astrocyte and microglial phagocytosis of Aβ, and mitigates amyloid plaque formation at least in mice. The findings, reported in the December 16 Science Translational Medicine, connect the circadian clock to glial responses in AD. Oddly, YKL-40 itself seems to have no circadian rhythm. ....
Protein involved in removing Alzheimer's buildup linked to circadian rhythm medicalxpress.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from medicalxpress.com Daily Mail and Mail on Sunday newspapers.