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United States , United Kingdom , Chapel Hill , Noord Holland , Sanja Potgieter , Mary Hicks , Shashi Kumar Suman , Futureco Bioscience , Favio Garc , Phoolwanti Rani , Favio Garcia , Daniel Peters , Kanika Jain , Gaye Brunson , Magdalena Margiotta , Ivan Shlamovitz , Calin Znamirovschi , Ahmed Mostafasa , Oriol Daura Pich , Jacqueline Shin , Varun Singh Kushwah , Irina Fenton , Janak Joshi , Brian Lananna , Ahmed Mostafa , Edward Tutu ,

Not Just a Biomarker: YKL-40 Links Glial Clock to Amyloidosis


22 Dec 2020
Many people with Alzheimer’s wake up frequently at night, nap excessively during the day, and lose their sense of time. Besides sleep cycles, the circadian clock also controls astrocyte and microglia activation, and knocking out one of the core clock genes, Bmal1, hastens plaque formation and promotes neuroinflammation and synaptic damage. Now, researchers led by Erik Musiek and Brian Lananna at Washington University in St. Louis report that Bmal1 regulates the gene for YKL-40, a marker of Alzheimer’s disease. Further, deleting the YKL-40 gene, Chi3l1, alters glial inflammatory responses, promotes astrocyte and microglial phagocytosis of Aβ, and mitigates amyloid plaque formation at least in mice. The findings, reported in the December 16 Science Translational Medicine, connect the circadian clock to glial responses in AD. Oddly, YKL-40 itself seems to have no circadian rhythm. ....

United States , Comunidad Autonoma De Cataluna , Erik Musiek , Helen Santoro , Brian Lananna At Washington University In St , Brian Lananna , Washington University , Translational Medicine , Alberto Lle , Memory Unit , Neurology Department , Hospital De La Santa Creu , Sant Pau , Knight Alzheimer , Disease Research Center , ஒன்றுபட்டது மாநிலங்களில் , காமுனிடட தன்னாட்சி டி கடலுள் , ஹெலன் சாண்டோரோ , வாஷிங்டன் பல்கலைக்கழகம் , மொழிபெயர்ப்பு மருந்து , நினைவு அலகு , நரம்பியல் துறை , மருத்துவமனை டி லா சாந்தா கிரேடு , சந்த் பா , நைட் முதுமறதி , நோய் ஆராய்ச்சி மையம் ,

Protein involved in removing Alzheimer's buildup linked to circadian rhythm