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Understanding the Impact of COSMIC-311 and Sequencing in DTC

Marcia Brose, MD, examines data from the COSMIC-311 study, emphasizing the importance of promptly initiating second-line therapy for patients who have progressed on first-line treatments. ....

Optimizing Therapy , Cosmic 311 , Braf Mutations , Braf Inhibitor , Braf V600e , Tumor Shrinkage , Ocular Toxicities , Cardiac Toxicities ,

FDA Approves Encorafenib Plus Binimetinib for BRAF V600E+ Metastatic NSCLC

The FDA has approved encorafenib (Braftovi) plus binimetinib (Mektovi) for adult patients with metastatic non–small cell lung cancer harboring a BRAF V600E mutation, as detected by an FDA-approved test. ....

Encorafenib Braftovi , Pfizer Inc , Updated October , Non Small Cell Lung Cancer , Lung Cancer , Braf V600e ,

ABM-1310 Receives FDA Fast Track Designation for BRAF V600E+ Glioblastoma

The FDA has granted fast track designation to ABM-1310 for the treatment of patients with glioblastoma harboring BRAF V600E mutations. ....

United States , Zane Yang , Response Assessment , Abm 1310 , Braf V600e , Fast Track Designation ,

FDA Approval Sought for Tovorafenib in Relapsed or Progressive Pediatric Low-Grade Glioma

A rolling new drug application seeking the approval of tovorafenib monotherapy for the treatment of patients with relapsed or progressive pediatric low-grade glioma has been submitted to the FDA. ....

Jeremy Bender , Response Assessment , Neuro Oncology High Grade Glioma , Day One Biopharmaceuticals , Day One , Pediatric Neuro Oncology Low Grade Glioma , Neuro Oncology Low Grade Glioma , Brain Cancer , Low Grade Glioma , Braf V600e ,

Encorafenib Plus Cetuximab/Binimetinib Displays Activity, Safety in BRAF V600E–mutant mCRC

Triplet therapy consisting of encorafenib, cetuximab, and binimetinib demonstrated activity and manageable safety as first-line treatment for patients with BRAF V600E–mutated metastatic colorectal cancer. ....

Van Cutsem , Dimension Or European Organization For Research , Cancer Symposium , Level Euroqol , European Organization , Cancer Qol Questionnaire Core , Patient Global Impression , Braf V600e Mutated Metastatic Colorectal Cancer , Braf V600e ,