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Discovery of a new genetic cause of hearing loss illuminates how inner ear works

A gene called
GAS2 plays a key role in normal hearing, and its absence causes severe hearing loss, according to a study led by researchers in the Perelman School of Medicine at the University of Pennsylvania.
Developmental Cell, discovered that the protein encoded by
GAS2 is crucial for maintaining the structural stiffness of support cells in the inner ear that normally help amplify incoming sound waves. They showed that inner ear support cells lacking functional
GAS2 lose their amplifier abilities, causing severe hearing impairment in mice. The researchers also identified people who have
GAS2 mutations and severe hearing loss.
“Anatomists 150 years ago took pains to draw these support cells with the details of their unique internal structures, but it’s only now, with this discovery about ....

United States , Benjaminl Prosser , John Oghalai , Tingfang Chen , Douglasj Epstein , Alex Rohacek , National Institutes Of Health , Keck School Of Medicine , Boucai Innovation Fund In Auditory Genomics , National Science Foundation , Perelman School Of Medicine , Radboud University Medical Center , University Of Pennsylvania , Heinsius Houbolt Foundation , Perelman School , Developmental Cell , Penn Medicine , Keck School , Hannie Kremer , National Institutes , Boucai Innovation Fund , Auditory Genomics , Heinsius Houbolt , ஒன்றுபட்டது மாநிலங்களில் , தேசிய நிறுவனங்கள் ஆஃப் ஆரோக்கியம் , கேக்க் பள்ளி ஆஃப் மருந்து ,

Discovery of a new genetic cause of hearing loss illuminates how inner ear works

PHILADELPHIA A gene called
GAS2 plays a key role in normal hearing, and its absence causes severe hearing loss, according to a study led by researchers in the Perelman School of Medicine at the University of Pennsylvania.
Developmental Cell, discovered that the protein encoded by
GAS2 is crucial for maintaining the structural stiffness of support cells in the inner ear that normally help amplify incoming sound waves. They showed that inner ear support cells lacking functional
GAS2 lose their amplifier abilities, causing severe hearing impairment in mice. The researchers also identified people who have
GAS2 mutations and severe hearing loss. ....

Pennsylvania Hospital , United States , New Jersey , University Of Pennsylvania , Benjaminl Prosser , John Oghalai , Tingfang Chen , Douglasj Epstein , Alex Rohacek , Penn Medicine Princeton Health , National Institutes Of Health , Lancaster Behavioral Health Hospital , Keck School Of Medicine , Boucai Innovation Fund In Auditory Genomics , National Science Foundation , Perelman School Of Medicine , University Of Pennsylvania Health System , Radboud University Medical Center , Princeton House Behavioral Health , Ruth Perelman School Of Medicine , Hospital Of The University Pennsylvania , Heinsius Houbolt Foundation , Perelman School , Developmental Cell , Penn Medicine , Keck School ,