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"[<sup>18</sup>F]NaF PET/CT imaging of response to single fraction SABR" by Nicholas Hardcastle, Yang Liu et al.

Breast cancer commonly metastasises to the skeleton, and stereotactic ablative body radiation therapy (SABR) is an emerging treatment for oligometastatic disease. Accurately imaging bone metastases and their response to treatment is challenging. [18F]NaF-PET has a higher sensitivity and specificity than conventional bone scans for detecting breast cancer bone metastases. In this pre-defined secondary analysis of a prospective trial, we evaluated the change in [18F]NaF uptake after SABR. Patients with oligometastatic breast cancer received a single fraction of 20 Gy to up to three bone metastases. [18F]NaF-PET was acquired before and 12 months after SABR. Pre- and post-treatment [18F]NaF-PET images were registered to the treatment planning CT. The relative change in tumour SUVmax and SUVmean was quantified. The intersection of each of the radiation therapy isodose contours with a non-tumour bone was created. The change in SUVmean in sub-volumes of non-tumour bone receiving doses of 0� ....

Bone Metastases , Af Pet , Sodium Fluoride ,

Cardiovascular Risk and Menopausal Symptoms Associated With Oral SERDs

Drs Vidula and Lu review the potential impact of cardiovascular health associated with oral selective estrogen receptor degraders (SERDs) and discuss how the risk of menopausal symptoms differ between oral SERDs and other endocrine therapies. ....

Neelima Vidula , Janice Lu , Ryan Haumschild , Estrogen Receptors Degraders , Er Her2 Metastatic Breast Cancer , Bone Health , Bone Metastases , Bone Density Scan , Pot Menopausal , Menopausal Symptoms , Emerald Study ,