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Eli Lilly/AbCellera s COVID-19 variant-targeting antibody enters clinical trials
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New AbCellera-Discovered Antibody that Neutralizes Viral Variants of COVID-19, LY-CoV1404, Enters Clinical Trials
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Baylor to test new drug against coronavirus variants
The monoclonal antibody neutralizes all known variants of concern, early trials show
Baylor Scott & White Health’s Dallas campus, which includes Baylor University Medical Center.(Baylor Scott & White)
A new treatment that shows promise in fighting coronavirus variants is going into clinical trials in North Texas.
The treatment, a monoclonal antibody from Eli Lilly and Vancouver-based AbCellera Biologics, neutralized all known variants of concern in preliminary lab tests, including variants first identified in the United Kingdom, South Africa, Brazil, California and New York, AbCellera announced Tuesday morning.
“It [attaches to] the virus in a way that allows it to stop every variant that we have currently seen globally,” said AbCellera CEO Carl Hansen in an interview. He added that it also appears capable of neutralizing the so-called double mutant strain found in India.
Apr 8, 2021 8:30am Because of its potency, COVID-19 antibody bamlanivimab could be paired with another antibody to potentially protect against coronavirus variants, Eli Lilly partner AbCellera said. (matejmo/Getty Images)
The U.S. government recently stopped distributing Eli Lilly’s COVID-19 antibody bamlanivimab as a single agent out of concern that it may not be effective against new coronavirus variants. But the drug’s original developer, AbCellera, believes it can still serve as a valuable component of combination therapies.
Among a panel of 24 antibodies identified from patients who recovered from COVID-19, bamlanivimab, also coded as LY-CoV555, showed the strongest ability to bind to and neutralize the SARS-CoV-2 virus that causes the disease in lab dishes. It also stopped the virus from replicating in the respiratory tract of monkeys, according to results published in Science Translational Medicine.