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"Protective Effect of Purinergic P2X7 Receptor Inhibition on Acrolein-I" by Zhinoos Taidi, Kylie J. Mansfield et al.

Patients undergoing chemotherapy with cyclophosphamide experience cystitis due to excretion of a toxic metabolite, acrolein. Cystitis, an inflammation of the bladder, is associated with damage to the integrity of the urothelial barrier. The purinergic P2X7 receptor (P2X7R) is increasingly recognized for its role in inflammation and cell death. P2X7R is expressed abundantly on the bladder urothelium. The aim of this study was to investigate the role of P2X7R in acrolein-induced inflammatory damage in primary cultured porcine bladder urothelial cells. Confluent urothelial cells in culture were treated with acrolein to induce damage; also, with the P2X7R selective antagonist, A804598. Cell viability assay, immunocytochemistry, and trans-epithelial electrical resistance (TEER) studies were carried out to investigate the effect of treatments on urothelial cell function. Acrolein induced a significant reduction in urothelial cell viability, which was protected by the presence of A804598 (10 ....

Bladder Inflammation , Interstitial Cystitis , Urinergic P2x7 Receptor , Urinergic Receptors , Rothelial Permeability ,

CNN CNN Newsroom Live November 10, 2019 09:41:00

If your adventure. keeps turning into unexpected bathroom trips. you may have overactive bladder, or oab. not again! we re seeing a doctor when we get home. myrbetriq treats oab symptoms of urgency, frequency, and leakage. it s the first and only oab treatment in its class. myrbetriq may increase blood pressure. tell your doctor right away if you have trouble emptying your bladder or have a weak urine stream. myrbetriq may cause serious allergic reactions, like swelling of the face, lips, throat or tongue, or trouble breathing. if experienced, stop taking and tell your doctor right away. myrbetriq may interact with other medicines. tell your doctor if you have liver or kidney problems. common side effects include increased blood pressure, common cold or flu symptoms, sinus irritation, dry mouth, urinary tract infection, bladder inflammation, back or joint pain, constipation, dizziness, and headache. looking for a destination that isn t always the bathroom? ....

Bathroom Trips , Overactive Bladder , Blood Pressure , Oab Treatment , Kidney Problems , Urine Stream , Myrbetriq May , Isn T , Side Effects , Bladder Inflammation , Urinary Tract Infection , Sinus Irritation , Dry Mouth ,

CNN CNN Tonight With Don Lemon November 7, 2019 08:34:00

If your adventure. keeps turning into unexpected bathroom trips. you may have overactive bladder, or oab. not again! we re seeing a doctor when we get home. myrbetriq treats oab symptoms of urgency, frequency, and leakage. it s the first and only oab treatment in its class. myrbetriq may increase blood pressure. tell your doctor right away if you have trouble emptying your bladder or have a weak urine stream. myrbetriq may cause serious allergic reactions, like swelling of the face, lips, throat or tongue, or trouble breathing. if experienced, stop taking and tell your doctor right away. myrbetriq may interact with other medicines. tell your doctor if you have liver or kidney problems. common side effects include increased blood pressure, common cold or flu symptoms, sinus irritation, dry mouth, urinary tract infection, bladder inflammation, back or joint pain, constipation, dizziness, and headache. looking for a destination that isn t always the bathroom? ask your doctor if myrbetriq ....

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MSNBC The 11th Hour With Brian Williams November 6, 2019 07:41:00

Common cold or flu symptoms, sinus irritation, dry mouth, urinary tract infection, bladder inflammation, back or joint pain, constipation, dizziness, and headache. looking for a destination that isn t always the bathroom? ask your doctor if myrbetriq is right for you. and visit myrbetriq.com. you do you know if mr. giuliani holds any security clearance of any kind? i don t know the answer to ....

Isn T , Dry Mouth , Urinary Tract Infection , Sinus Irritation , Bladder Inflammation , Visit Myrbetriq Com , Rudy Giuliani , Security Clearance ,

MSNBC The 11th Hour With Brian Williams November 5, 2019 07:40:00

Like swelling of the face, lips, throat or tongue, or trouble breathing. if experienced, stop taking and tell your doctor right away. myrbetriq may interact with other medicines. tell your doctor if you have liver or kidney problems. common side effects include increased blood pressure, common cold or flu symptoms, sinus irritation, dry mouth, urinary tract infection, bladder inflammation, back or joint pain, constipation, dizziness, and headache. looking for a destination that isn t always the bathroom? ask your doctor if myrbetriq is right for you. and visit myrbetriq.com. in t easy. 12 hours? 20 dogs? where s your belly rubs? after a day of chasing dogs you shouldn t have to chase down payments. (vo) send invoices and accept payments to get paid twice as fast. (danny) it s time to get yours! (vo) quickbooks. backing you. sorry for this reminder, but almost exactly one year to go now before the 2020 election. two new national polls are painting a pretty clear picture of the democra ....

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