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New wireless biosensor technology could revolutionize healthcare

A wireless biosensor, developed by a Malmö University researcher, enables a more patient-controlled system whereby infections can be detected much earlier through smart catheters, smart diapers or wound dressings. ....

Atefeh Shafaat ,

"Dysregulated NAD(H) homeostasis associated with ciprofloxacin toleranc" by Joanna Urbaniec, Martina Sanderson-Smith et al.

Introduction: Antibiotic persistence (subpopulation tolerance) occurs when a subpopulation of antibiotic sensitive cells survives prolonged exposure to a bactericidal concentration of an antibiotic, and is capable of regrowth once the antibiotic is removed. This phenomenon has been shown to contribute to prolonged treatment duration, infection recurrence, and accelerated development of genetic resistance. Currently, there are no biomarkers which would allow for segregation of these antibiotic-tolerant cells from the bulk population prior to antibiotic exposure, limiting research on this phenomenon to retrograde analyses. However, it has been previously shown that persisters often have a dysregulated intracellular redox homeostasis, warranting its investigation as a potential marker for antibiotic tolerance. Furthermore, it is currently unknown whether another antibiotic tolerant subpopulation - viable but non-culturable cells (VBNCs), are simply persisters with extreme lag phase, or ar ....

Escherichia Coli , Single Cell ,