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New software tool provides a way for safer design of genome editing

A team of researchers has developed a software tool called DANGER (Deleterious and ANticipatable Guides Evaluated by RNA-sequencing) analysis that provides a way for the safer design of genome editing in all organisms with a transcriptome. ....

Hidemasa Bono , Megan Craig , Kazuki Nakamae , Hiroshima University , Japan Society For The Promotion Of Science , Technology Agency , Genome Editing Innovation Center , Ptbio Inc , Ptbio Collaborative Research Laboratory , Guides Evaluated , Bioinformatics Advances , Bio Digital Transformation , Japan Science , Japan Society , Genome Editing ,

Researchers develop DANGER analysis tool for the safer design of gene editing

Researchers develop DANGER analysis tool for the safer design of gene editing
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Kazuki Nakamae , Hidemasa Bono , Ptbio Inc , Technology Agency , Japan Society For The Promotion Of Science , Genome Editing Innovation Center , Hiroshima University , Ptbio Collaborative Research Laboratory , Guides Evaluated , Bioinformatics Advances , Bio Digital Transformation , Japan Science , Japan Society ,

Researchers develop DANGER analysis tool for

<p>A team of researchers has developed a software tool called DANGER (Deleterious and ANticipatable Guides Evaluated by RNA-sequencing) analysis that provides a way for the safer design of genome editing in all organisms with a transcriptome. For about a decade, researchers have used the CRISPR technology for genome editing. However, there are some challenges in the use of CRISPR. The DANGER analysis overcomes these challenges and allows researchers to perform safer on- and off-target assessments without a reference genome. It holds the potential for applications in medicine, agriculture, and biological research.</p>
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Hidemasa Bono , Kazuki Nakamae , Japan Society For The Promotion Of Science , Technology Agency , Ptbio Collaborative Research Laboratory , Ptbio Inc , Genome Editing Innovation Center , Hiroshima University , Guides Evaluated , Bioinformatics Advances , Bio Digital Transformation , Japan Science , Japan Society ,