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Cellular Uptake
The cellular uptake properties of the proteins labeled with FITC were analyzed by flow cytometry. The uptake of HFtn by tumor cells was mediated by TfR1 has been proved previously. As shown in Figure 3, cellular uptake of HFtn was much higher than that of free FITC, which is probably attributed to the TfR1 receptor-mediated endocytosis. Significantly, the mean fluorescence intensity of FITC-tLyP-1-HFtn was approximately three-fold higher than FITC-HFtn, suggesting that the enhanced intracellular uptake of tLyP-1-HFtn was probably attributed to TfR1 and NRP-1 dual receptor-mediated endocytosis. In contrast, FITC-M-tLyP-1-HFtn showed similar mean fluorescence intensity as the FITC-HFtn, indicating that the mutation at the tLyP-1 peptide sequence resulted in the inactivation of the NRP-1 receptor-mediated endocytosis. ....

United States , Zhejiang Tianhang Biotechnology Co Ltd , Biosharp Life Sciences , Co Ltd , Laboratory Animal Co , Chinese Academy Of Sciences Shanghai , Energy Chemical Shanghai , Transgen Biotech Co Ltd , Shanghai Yuanye Biotechnology Co Ltd , Guangzhou Saiguo Biotech Co Ltd , Ge Healthcare , C End Rule , Takara Biotech , Energy Chemical , Beyotime Biotechnology , Biosharp Life , Nanjing Keygen , Chinese Academy , Bio Logic Science Instruments , Drug Loading , Cell Migration Inhibition , Apoptosis Assay , Three Dimensional Tumor , Cell Migration , Inhibition Effect , ஒன்றுபட்டது மாநிலங்களில் ,