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Drugs create balancing act for patients with non-small cell lung cancer


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The results of a large, retrospective study of patients who received a form of immunotherapy for non-small cell lung cancer (NSCLC) revealed that patients may get more than one immune-related side effect, and identified a correlation between these multisystem immune-related adverse events (irAEs) and improved patient survival. In fact, patients who developed two irAEs did better, in terms of delaying the time to cancer progression and overall survival, than those who developed only one irAE. According to the researchers, this new information will be helpful in discussing with patients the spectrum of immune side effects that may occur from immunotherapy and the implications for their survival. ....

Johns Hopkins Hospital , United States , North Carolina , Ohio State University , National Institutes Of Health , Dana Farber Cancer Institute , East Carolina University , Dwight Owen , Shunichi Sugawara , Christine Hann , Abdul Rafeh Naqash , Gregory Otterson , David Ettinger , Paul Walker , Jiajia Zhang , Bairavi Shankar , Julie Brahmer , Josephine Feliciano , Biagio Ricciuti , Patrick Forde , Sandip Patel , Jarushka Naidoo , Kristen Marrone , James Comprehensive Cancer Center , University Of Perugia , Kimmel Cancer Center ,