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Abstract Biosafety Level 4 labs are in the spotlight as speculation swirls that Covid-19 may have emerged from such a facility in either China or the US. In the US, the mass proliferation of high-containment germ labs since 9/11, and its track record of safety lapses, remains a concern with the renewed interest in the field of biodefense. In light of past accidents of anthrax leaks in US labs and SARS leak in Chinese labs, there needs to be improved regulation and governance of germ labs in order to mitigate rising risks of accidents that threaten public health, redress safety lapse providing easy access of pathogens by terrorists, and prevent a biodefense arms race. ....