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Weizmann Institute Optogeneticists Use Mosquito Rhodopsins to Boost Brain Research


Weizmann Institute Optogeneticists Use Mosquito Rhodopsins to Boost Brain Research
New versions of light-sensitive proteins could illuminate the dark corners of our brain’s communication pathways
Weizmann Institute of Science
Segment of a mouse brain. Red illuminated areas are communication pathways between neurons that express the mosquito-derived protein. In blue: cells’ nuclei
Weizmann Institute of Science
Illustration of the mosquito rhodopsin’s structure. Efficient and stable
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Newswise Can a protein found in a mosquito lead to a better understanding of the workings of our own brains? Prof. Ofer Yizhar and his team in the Weizmann Institute of Science’s Department of Neurobiology took a light-sensitive protein derived from mosquitos and used it to devise an improved method for investigating the messages that are passed from neuron to neuron in the brains of mice. This method, reported in ....

Simon Wiegert , Ofer Yizhar , Inbar Saraf Sinik , Shaked Palgi , Pritish Patil , Jonas Wietek , Hanna Litvin , Ido Davidi , Eyal Bitton , Mathias Mahn , Benjamin Rost , Dietmar Schmitz , Berlin University Of Medicine , Institute For Brain , Weizmann Institute , Weizmann Institute Of Science Department Neurobiology , Neural Sciences , Julien Dine , Rivka Levy , Asaf Gat , Molecular Neurobiology Hamburg , Berlin University , Friedrich Miescher Institute , Biomedical Research , Ptogenetics Rhodopsin Mosquito Neuroscience Neurotransmitter Synapses , All Journal News ,

Brain Research Gets a Boost from Mosquitos


Weizmann Institute of Science
Can a protein found in a mosquito lead to a better understanding of the workings of our own brains? Prof. Ofer Yizhar and his team in the Weizmann Institute of Science’s Neurobiology Department took a light-sensitive protein derived from mosquitos and used it to devise an improved method for investigating the messages that are passed from neuron to neuron in the brains of mice. This method, reported today in Neuron, could potentially help scientists solve age-old cerebral mysteries that could pave the way for new and improved therapies to treat neurological and psychiatric conditions.
Yizhar and his lab team develop so-called optogenetic methods – research techniques that allow them to “reverse engineer” the activity of specific brain circuits in order to better understand their function. Optogenetics uses proteins known as rhodopsins to control the activity of neurons in the mouse brain. Rhodopsins are light-sensing proteins – they ....

Ofer Yizhar , Simon Wiegert , Inbar Saraf Sinik , Shaked Palgi , Pritish Patil , Jonas Wietek , Hanna Litvin , Ido Davidi , Eyal Bitton , Dietmar Schmitz , Benjamin Rost , Mathias Mahn , Weizmann Institute Of Science Neurobiology Department , Institute For Brain , Charite Research Hospital , Weizmann Institute , Neural Sciences , Friedrich Miescher Institute For Biomedical Research , Neurobiology Department , Julien Dine , Rivka Levy , Asaf Gat , Molecular Neurobiology , Friedrich Miescher Institute , Biomedical Research , வெய்ஸ்மேன் நிறுவனம் ஆஃப் அறிவியல் நரம்பியல் துறை ,

Brain Research Gets a Boost from Mosquitos - Life Sciences | Weizmann Wonder Wander


Can a protein found in a mosquito lead to a better understanding of the workings of our own brains? Prof. Ofer Yizhar and his team in the Weizmann Institute of Science’s Neurobiology Department took a light-sensitive protein derived from mosquitos and used it to devise an improved method for investigating the messages that are passed from neuron to neuron in the brains of mice. This method, reported today in
Neuron, could potentially help scientists solve age-old cerebral mysteries that could pave the way for new and improved therapies to treat neurological and psychiatric conditions.
Yizhar and his lab team develop so-called optogenetic methods – research techniques that allow them to “reverse engineer” the activity of specific brain circuits in order to better understand their function. Optogenetics uses proteins known as rhodopsins to control the activity of neurons in the mouse brain. Rhodopsins are light-sensing proteins – they are most known for their role ....

Simon Wiegert , Ofer Yizhar , Inbar Saraf Sinik , Shaked Palgi , Pritish Patil , Jonas Wietek , Hanna Litvin , Ido Davidi , Eyal Bitton , Mathias Mahn , Benjamin Rost , Dietmar Schmitz , Weizmann Institute Of Science Neurobiology Department , Institute For Brain , Charite Research Hospital , Weizmann Institute , Friedrich Miescher Institute For Biomedical Research , Neural Sciences , Neurobiology Department , Julien Dine , Rivka Levy , Asaf Gat , Molecular Neurobiology , Friedrich Miescher Institute , Biomedical Research , வெய்ஸ்மேன் நிறுவனம் ஆஃப் அறிவியல் நரம்பியல் துறை ,