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The clinical outcome of the disease provoked by the Sars-CoV-2 infection, COVID-19, is largely due to the development of interstitial pneumonia accompanied by an Acute Respiratory Distress Syndrome (ARDS), often requiring ventilatory support therapy in Intensive Care Units (ICUs). Current epidemiologic evidence is demonstrating that the COVID-19 prognosis is significantly influenced by its acute complications. Among these, delirium figures as one of the most frequent and severe, especially in the emergency setting, where it shows a significantly negative prognostic impact. In this regard, the aim of our study is to identify clinical severity factors of delirium complicating COVID-19 related-ARDS. We performed a comparative and correlation analysis using demographics, comorbidities, multisystemic and delirium severity scores and anti-delirium therapy in two cohorts of ARDS patients with delirium respectively due to COVID-19 (n=40) or other medical conditions (n=39). Our results indicate

United statesSachsen anhaltOspedale maggiore policlinicoPaolo brambillaAnesth analgGranda ospedale maggiore policlinicoAmerican psychiatric associationDefinition taskGroup correlationsWorld health organizationEthics committee milan areaCare study groupBrain behav immun healthAmerican psychiatric publishing incEthics committee of the fondazioneIntensive care units