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X-ray Ptychography performed for first time at small-scale Laboratory Source

X-ray Ptychography performed for first time at small-scale Laboratory Source
labnews.co.uk - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from labnews.co.uk Daily Mail and Mail on Sunday newspapers.

Darren Batey , Paul Quinn , Ghent University Credit , University College London , Diamond Light Source Ltd , University Of Sheffield Soft Matter Analytical Laboratory , Laboratoryx Ray , Ghent University , University Of Sheffield , Diamond Light Source , Physical Review Letters , Beamline Scientist , Sheffield Soft Matter Analytical Laboratory , டேரன் பேட்டி , பால் க்வின் , பல்கலைக்கழகம் கல்லூரி லண்டன் , வைரம் ஒளி மூல லிமிடெட் , கெஂட் பல்கலைக்கழகம் , பல்கலைக்கழகம் ஆஃப் ஷெஃபீல்ட் , வைரம் ஒளி மூல , உடல் விமர்சனம் எழுத்துக்கள் ,

Can X-ray Ptychography be used in Smaller Laboratory Source Facilities?

May 12 2021
X-ray ptychography has recently opened up applications across physical and life sciences at large-scale synchrotron facilities such as the UK’s Diamond Light Source, by producing quantitative phase images with the highest possible spatial resolutions (10’s nm) – going well beyond the conventional limitations of the available X-ray optics. Now an international collaboration of scientists has demonstrated for the first time how the technique of high-resolution phase contrast diffraction imaging can be performed with small-scale laboratory sources.
The team from Diamond Light Source, Ghent University, University of Sheffield, and University College London conducted an experiment with a compact liquid metal-jet (LMJ) X-ray source. Laboratory X-ray sources have significantly lower levels of brilliance but currently provide the X-ray synchrotron user community with access to micro-CT, where they can gain a great deal of experience and p ....

United Kingdom , Frederic Van Assche , Paul Quinn , Oleksandro Mykhaylyk , Andrewj Parnell , Christoph Rau , Sander Vanheule , Darren Batey , Darrenj Batey , Silvia Cipiccia , University College London , Laboratory Source , Matter Analytical Laboratory , Department Of Medical Physics , Laboratoryx Ray , Ghent University , University Of Sheffield , Department Of Chemistry , University Of Sheffield Soft Matter Analytical Laboratory , Department Of Physics , Diamond Light Source , Beamline Scientist , Sheffield Soft Matter Analytical Laboratory , Physical Review Letters , X Ray Ptychography , Van Assche ,

Massive Fragment Screen Points Way to New SARS-CoV-2 Inhibitors

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This news release, originally issued by Diamond Light Source, describes a template for how to develop directly-acting antivirals that would combat COVID-19. The study focused on a specific part of the Nsp3 gene that SARS-CoV-2 uses to suppress the host cell’s natural antiviral response. Researchers from the University of California used the Highly Automated Macromolecular Crystallography (AMX) and the Frontier Microfocusing Macromolecular Crystallography (FMX) beamlines at the National Synchrotron Light Source II (NSLS-II) to characterize the molecular structure of proteins involved in this mechanism. The beamlines ultrasmall yet powerful x-rays and rapid sample mounting automation enabled the researchers to collect hundreds of high-resolution datasets per eight-hour shift. NSLS-II is a U.S. Department of Energy (DOE) Office of Science User Facility at DOE’s Brookhaven National Laboratory that offers a comprehensive suite of life science research capabilities ....

United States , University Of California San Francisco , Cara Laasch , University Of California , University Of Oxford , Us Department Of Energy , Office Of Science User Facility , National Synchrotron Light Source , Structural Biology Consortium , Brookhaven National Laboratory , Diamond Light Source , Highly Automated Macromolecular Crystallography , Science User Facility , National Laboratory , Fragment Screen Points Way , Beamline Scientist , Science Advances , Biology Consortium , California San , ஒன்றுபட்டது மாநிலங்களில் , பல்கலைக்கழகம் ஆஃப் கலிஃபோர்னியா சான் பிரான்சிஸ்கோ , பல்கலைக்கழகம் ஆஃப் கலிஃபோர்னியா , பல்கலைக்கழகம் ஆஃப் ஆக்ஸ்ஃபர்ட் , எங்களுக்கு துறை ஆஃப் ஆற்றல் , அலுவலகம் ஆஃப் அறிவியல் பயனர் வசதி , தேசிய ஒத்திசைவு ஒளி மூல ,

Massive fragment screen points way to new SARS-CoV-2 inhibitors

Experiment with 2533 fragments compounds generates chemical map to future antiviral agents 
Principal Beamline Scientist on I04, Frank von Delft. 
New research published in
Science Advances provides a template for how to develop directly-acting antivirals with novel modes of action, that would combat COVID-19 by suppressing the SARS-CoV-2 viral infection. The study focused on the macrodomain part of the Nsp3 gene product that SARS-CoV-2 uses to suppress the host cell’s natural antiviral response. This part of the virus’s machinery, also known as Mac1, is essential for its reproduction: previous studies have shown that viruses that lack it cannot replicate in human cells, suggesting that blocking it with a drug would have the same effect.  ....

University Of Oxford , Structural Biology Consortium , University Of California San Francisco , Beamline Scientist , Science Advances , Biology Consortium , California San , Drug Discovery , Medicinal Chemistry , Antiviral Drug , Molecular Modelling , Natural Sciences , Protein Structure , X Ray Crystallography , பல்கலைக்கழகம் ஆஃப் ஆக்ஸ்ஃபர்ட் , பல்கலைக்கழகம் ஆஃப் கலிஃபோர்னியா சான் பிரான்சிஸ்கோ , உயிரியல் கூட்டமைப்பு , கலிஃபோர்னியா சான் , உயிர் தகவலியல் , மருந்து கண்டுபிடிப்பு , மருத்துவ வேதியியல் , மூலக்கூறு மாடலிங் , இயற்கை அறிவியல் , ப்ரோடீந் அமைப்பு ,

Numerous agents with anti-SARS-CoV-2 potential discovered with crystallographic screening

Numerous agents with anti-SARS-CoV-2 potential discovered with crystallographic screening
news-medical.net - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from news-medical.net Daily Mail and Mail on Sunday newspapers.

Angela Betsaidab Laguipo , Angela Betsaida , Science Advances , Beamline Scientist ,