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Cureus | Neonatal Cholestasis: The Changing Etiological Spectrum in Pakistani Children

Objectives: To determine the frequency of clinical presentation and laboratory profile in the diagnosis of the etiological spectrum of neonatal cholestasis.

Material and methods: In this prospective cross-sectional study, we recruited children who presented with jaundice and direct hyperbilirubinemia with onset in the first three months of life. The study was conducted between April 2019 to March 2021 (24 months) at the Government Lady Reading Hospital of Khyber Pakhtunkhwa province in Pakistan. The diagnosis was based on history and clinical findings that included jaundice, stool color, itching, abdominal distention, and deranged liver function tests and confirmed on liver biopsy and specific diagnostic tests. Data was recorded and analyzed using SPSS version 20 (IBM Corp., Armonk, NY).

Results: A total of 90 children were included in the study, out of which 65.6% were male. The average age was recorded as 118.01 days + 118.1 SD. Jaundice, dark urine, and hepatome ....

North West Frontier , Lady Reading Hospital , New South Wales , Bazlul Karim , Intrahepatic Cholestasis , Department Of Child Health , Government Lady Reading Hospital , Khyber Pakhtunkhwa , Child Health , Familial Intrahepatic Cholestasis , Iron Storage Disease , Pick Disease , Storage Disease , Neonatal Hepatitis , Common Bile ,