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Anxiety Linked to Gut Microbial Metabolite in Mouse and Human

A study comparing mice engineered to synthesize the metabolite 4EPS, to mice that cannot, shows the metabolite passes into the brain and dampens maturation of oligodendrocytes, thinning the myelin insulation around axons. This results in anxiety-like behavior in mice that can be reversed by drugs that promote myelination. In an accompanying human study, the authors show a drug that adsorbs 4EPS from the human gut alleviates anxiety in adolescents with autism. ....

Sarkis Mazmanian , B Needham Caltech , Brittany Needham , Chrissy Chen Institute For Neuroscience At Caltech , Chrissy Chen Institute , Nature Medicine ,

A Microbial Compound in the Gut Leads to Anxious Behaviors in Mice

A small-molecule metabolite produced by gut bacteria in mice, can travel to the brain and alter brain cell function, inducing anxiety behaviors. ....

National Cheng Kung University , Tainan Municipality , United States , Jessica Griffiths , Masanori Funabashi , Zhuo Wang , Michael Fischbach , Joseph Boktor , Claire Rabut , Sarkis Mazmanian , Jong Hwang , Yumei Guo , Lori Dajose , Rob Knight , Mark Adame , Qiyun Zhu , B Needham Caltech , Wei Li Wu , Pamela Bjorkman , Brittany Needham , Mark Ladinsky , Daniel Geschwind , Daniel Holschneider , Jillian Haney , Mikhail Shapiro , Merkin Institute Professor ,