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New malaria vaccine strain shows promise in preclinical trials

In a report published on March 21, 2024 in EMBO Molecular Medicine (A replication competent Plasmodium falciparum parasite completely attenuated by dual gene deletion) investigators at Seattle Children's Research Institute and Sanaria Inc. describe the development of a whole malaria parasite vaccine strain that infects the liver, develops to the late liver stage, and then gets completely stuck and cannot burst out of the liver to cause symptomatic blood infection. ....

Burkina Faso , Hardik Patel , B Kim Lee Sim , Peter Kremsner , Stephenl Hoffman , Debashree Goswami , Centre De Recherches , University Of Washington , Seattle Children Research Institute , Ashley Vaughan At Seattle Children Research Institute , Department Of Pediatrics , Stefan Kappe At Seattle Children Research Institute , Institute For Tropical Medicine , Sanaria Inc , Seattle Children , Research Institute , Replication Competent , Stefan Kappe , Ashley Vaughan , Professor Peter Kremsner , Tropical Medicine ,