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A new Stemona alkaloid glycoside derivative, 6-hydroxy-5,6-seco-stemocurtisinoside (4), was isolated from the ethanolic extract of the aerial parts of Stemona curtisii Hook.f., together with stemocurtisine (1), (11Z)-1',2'-didehydrostemofoline (2) and 6-hydroxy-5,6-seco-stemocurtisine (3). Whereas, stemocurtisine (1), stemocurtisinol (5) and oxyprotostemonine (6) were isolated from the roots. Their structures were elucidated using 1D and 2D NMR spectroscopy as well as MS experiments. The extract and the pure isolated compounds were evaluated for their cytotoxicities and their larvicidal activities against the dengue vector, Aedes aegypti. The alkaloid 2 showed the strongest larvicidal activity with a LC50 value of 2.44 µM. While the alkaloid 3 exhibited cytotoxicity against MCF-7 and KB cells (IC50 values of 62.52 and 18.82 µM, respectively) and showed no significant cytotoxicity against Vero cells. Additionally, quantitative analysis of the most active compounds; 2 and 3 i ....
Again, when we re talking about scaling back our measures of prevention of infection, when we re talking that in a setting of when we know we have waning efficacy with the two doses and even if you have a booster, studies are showing by ten weeks out. i got any booster shot in september. by 10 weeks out, 30 % to 50% efficacy with that vaccine. and we may have b-cells and t-cells involved, but the question is do we want to risk that? do we want to risk infection of a virus when we don t know the long-term consequences and particularly, when our children are being involved, we as adults have to make adult decisions to say although i do not like it, i will risk, and i will sacrifice certain pleasures in order to protect the ones that cannot protect themselves. and that means wearing the masks. if i were talking to those who are in charge, i would say mandate n-95s. send them to every home, ....
Our aim should be to prevent severe disease, hospitalisation and death. Our aim should not be to prevent mild respiratory disease with scratchy throats. ....
Are thinking you are making the right decision by getting your kids vaccinated, and there still could be school closures. this is from fara, is the booster still effective for omicron? the answer is we don t know yet because we only have booster data out four weeks for pfizer and two weeks for moderna. that is antibody levels, four weeks after a booster, and in the case of moderna, four weeks after the booster. if we all talk about this, it s a three-shot series, it s a three-shot series, what does that mean when antibodies will start to wane, right? that s what they are supposed to do. your b cells and t cells and other parts of your immune system takes over to prevent ....