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Treatment Opportunities Continue to Advance in CLL Management

In crafting a patient-centered regimen, the convergence of expertise from physicians and pharmacists, paired with the values and preferences of patients, becomes paramount.

United statesUnited kingdomAamir aliZanubrutinib brukinsaEli lillyYijun caiisPirtobrutinib jaypircaMann school of pharmacyLilly united statesAbbvie incBeigene ltdAmerican society of clinical oncologyNational comprehensive cancer network incGenentech incAstrazeneca pharmaceuticalsNorris comprehensive cancer center

Cellecta, Inc Launches DriverMap™ Adaptive Immune Receptor (AIR) Mouse RNA TCR and BCR Kits for Sensitive Immune Repertoire Profiling

Cellecta, Inc Launches DriverMap™ Adaptive Immune Receptor (AIR) Mouse RNA TCR and BCR Kits for Sensitive Immune Repertoire Profiling
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Mountain viewUnited statesPaul diehlRuth mercadoAlex chenchikCellecta incHuman or mouse immune repertoire profiling serviceAdaptive immune receptorB cell receptorMouse immune repertoire profiling

Intensity Therapeutics Reports Second Quarter Financial Results and Provides Corporate Update

/PRNewswire/ Intensity Therapeutics, Inc. (Nasdaq: INTS), a clinical-stage biotechnology company focused on the discovery and development of proprietary,.

United statesEdna kaplanLewish benderBristol myers squibbMichael millerMerck sharpe dohmeAngel arnaoutOntario institute of cancer researchVaccine branchDevelopment rd expensesNational cancer instituteAmerican society of clinical oncologyDevelopment agreementIntensity therapeutics incCompany on twitter intensityincPrnewswire intensity therapeutics inc

Intensity Therapeutics Reports INT230-6 Can Cause Immune Priming in Historically Quiescent Breast Cancers

/PRNewswire/ Intensity Therapeutics, Inc. ("Intensity"), a clinical-stage biotechnology company focused on the discovery and development of proprietary,.

United statesEdna kaplanBristol myers squibbLewish benderMerck sharpe dohmeMichael millerAngel arnaoutApproval programAmerican society of clinical oncologyVaccine branchDevelopment agreementUniversity of ottawaNational cancer instituteHealth canadaOntario institute for cancer researchCompany on twitter

Frontiers | Notch2 Increases the Resistance to Venetoclax-Induced Apoptosis in Chronic Lymphocytic Leukemia B Cells by Inducing Mcl-1

Chronic lymphocytic leukemia (CLL) has experienced a clinical revolution thanks to the discovery of crucial pathogenetic mechanisms. CLL is still an incurable disease due to intrinsic or acquired resistance of the leukemic clone. Venetoclax is a Bcl-2 inhibitor with a marked activity in CLL, but emerging patterns of resistance are being described. We hypothesize that intrinsic features of CLL cells may contribute to drive mechanisms of resistance to venetoclax. We analyzed the expression of IRF4, Notch2 and Mcl-1 in a cohort of CLL patients. We evaluated CLL cells viability after genetic and pharmaceutical modulation of Notch2 expression in patients harboring trisomy 12. We tested venetoclax in trisomy 12 CLL cells either silenced or not for Notch2 expression or in combination with an inhibitor of Mcl-1, AMG-176. Trisomy 12 CLL cells were characterized by low expression of IRF4 associated with high levels of Notch2 and Mcl-1. Notch2 and Mcl-1 expression determined protection of CLL cel

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