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SLS009 Plus Venetoclax/Azacitidine Produces Responses in R/R AML, Including ASXL1+ Disease

SLS009 plus venetoclax and azacitidine elicited responses in patients with relapsed/refractory AML, particularly in those harboring ASXL1 mutations. ....

Angelos Stergiou , Life Sciences Group , Sciences Group , Hematologic Oncology , Acute Myeloid Leukemia ,

Gilead Discontinues Phase 3 ENHANCE-3 Trial of Magrolimab Plus Venetoclax/Azacitidine in AML

The phase 3 ENHANCE-3 study of magrolimab plus venetoclax/azacitidine vs venetoclax/azacitidine in select patients with AML has been terminated. ....

Merdad Parsey , Gilead Sciences Inc , World Health Organization , Gilead Sciences , Acute Myeloid Leukemia , Phase 3 Enhance Study Nct04313881 , Agrolimab , Acute Myeloid Leukemia Aml ,

Ziftomenib Combos Show Early Safety, Activity in NPM1-Mutant and KMT2A-Rearranged AML

An acceptable safety profile and early evidence of clinical activity was observed with ziftomenib plus standard regimens in select patients with AML. ....

Samer Zeidan , Division Of Hematologic Malignancies , Hematologic Malignancies , Hematology Early Therapeutics Research , Yale Cancer Center , Phase 1 2 Komet 007 Trial , Acute Myeloid Leukemia , Npm1 Mutant And Kmt2a Rearranged , Npm1 Mutant And Kmt2a Rearranged Aml , Cytarabine And Daunorubicin 7 3 ,

Oral HMAs May Provide Safer and More Effective Treatment Options for MDS

Guillermo Garcia-Manero, MD, spotlights the evolution of oral azacitidine- and decitabine-based regimens for MDS. ....

United States , Guillermo Garcia Manero , Translational Research , International Prognostic Scoring System , Division Of Cancer Medicine , University Of Texas Md Anderson Cancer Center , Department Of Leukemia , Faculty Senate , Myelodysplastic Syndromes , Cancer Medicine , Cancer Center , Revised International Prognostic Scoring System , Myeloproliferative Neoplasms , Oral Regimens , Decitabine Plus Cedazuridine , Azacitidine Plus Cedazuridine , Hypomethylating Agents ,

Authors Support Trials of Triplet Therapy in Higher-Risk MDS

Given the likelihood of MDS to progress to acute myeloid leukemia (AML), the authors state, “There are certain settings where ‘AML-like’ therapies are appropriate in MDS, particularly given our evolving understanding of the overlapping biology of these malignancies.” ....

Girish Venkataraman , Image Bank , Clinical Hematology International , Myelodysplastic Syndrome , Triplet Therapy ,