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New study provides insights about mosaic chromosomal alterations in diverse populations

As people age, the DNA in their cells begins to accumulate genetic mutations. Mosaic chromosomal alterations (mCAs), a category of mutations acquired in blood cells, are linked with a 10-fold increased risk of developing blood cancer. ....

United Kingdom , Yasminkaa Jakubek , Lily Ramsey , University Of Kentucky Markey Cancer Center , National Heart , Kentucky Markey Cancer Center , Nature Genetics , Blood Institute , Trans Omics , Precision Medicine , East Asian , United Kingdom College , Blood Cancer , Health Care , Next Generation , Precision Medicine ,

Investigational drug restores calcium levels in rare genetic disorder

An investigational drug, encaleret, restored calcium levels in people with autosomal dominant hypocalcemia type 1 (ADH1), a rare genetic disorder marked by an imbalance of calcium in the blood and urine, as well as abnormally low levels of parathyroid hormone, which regulates blood calcium levels. ....

Lily Ramsey , Rena Dsouza , Rachel Gafni , Michael Collins , Iris Hartley , Development Agreement , National Institutes Of Health Clinical Center , Division Of Intramural Bio Pharma Inc , Craniofacial Research , Calcilytix Therapeutics Inc , National Institute , National Institutes , Clinical Center , New England Journal , Renad Souza , Intramural Research , Bridgebio Pharma , Calcilytix Therapeutics , Cooperative Research , Clinical Trial , Genetic Disorder , Medical Research ,

Higher educational attainment may have a protective effect against Alzheimer's in people with genetic risk

A new study by researchers from Mass General Brigham further illustrates that when it comes to risk of Alzheimer's disease, even genetically determined forms of the disease, genetics is only one piece of the puzzle. ....

United States , Megan Craig , Familial Dementia Neuroimaging Lab , Mass General Brigham , Quiroz Phd , Massachusetts General , Massachusetts General Hospital , Mass Eye , Lzheimer 39s Disease , Ognitive Function ,

Copy number profiling provides insight as to why prostate cancer may become lethal

Researchers performed genome-wide copy number profiling of the androgen receptor (AR) on metastases from deceased prostate cancer patients. ....

Lightspring Shutterstock , Nature Communications , Prostate Cancer , Androgen Deprivation Therapy ,

Study detects biomarker changes nearly 30 years before symptom onset of Alzheimer's disease

A new paper has shown how Alzheimer’s disease pathology comes into being over a period of almost three decades. ....

Atthapon Raksthaput Shutterstock , Alzheimer Network , Nature Medicine , Dominantly Inherited Alzheimer Network , Mass Spectrometry , Positron Emission Tomography , Tau Protein ,