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Gene Therapy in Alzheimer's Disease Mouse Model Preserves Learning and Memory


Gene Therapy in Alzheimer’s Disease Mouse Model Preserves Learning and Memory
News release
Researchers at University of California San Diego School of Medicine, with colleagues elsewhere, have used gene therapy to prevent learning and memory loss in a mouse model of Alzheimer’s disease (AD), a key step toward eventually testing the approach in humans with the neurodegenerative disease.
The findings are published online in advance of the June 11, 2021 issue of
AD is characterized by the accumulation of clumps of misfolded proteins called amyloid plaques and neurofibrillary tau tangles, both of which impair cell signaling and promote neuronal death. Current AD treatments targeting plaques and tangles address only symptoms, which the study’s authors say suggests a reversal and cure of AD will likely require a combination of interventional approaches that both decrease aggregating toxins and promote neuronal and synaptic plasticity. ....

San Diego , United States , University Of California San Diego , Kimberly Zhou , Davidm Roth , Mehul Dhanani , Isabellac Kelly , Stevel Wagner , Paul Savchenko , Natalia Kleschevnikov , Shanshan Wang , Johnq Trojanowski , Alexander Kleschevnikov , Sonia Podvin , Piyushm Patel , Atsushi Miyanohara , Lou Gehrig , Phuong Nguyen , Josephs Leem , Ohio State University , National Institutes Of Health , Department Of Veterans Affairs , University Of Pennsylvania , Methods Clinical Development , Department Of Anesthesiology , Uc San Diego School Of Medicine ,