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Study clarifies the effect of aging on hematopoietic stem cells


Study clarifies the effect of aging on hematopoietic stem cells
By transferring mouse aged hematopoietic stem cells (aged HSCs) to the environment of young mice (bone marrow niche), it was demonstrated that the pattern of stem cell gene expression was rejuvenated to that of young hematopoietic stem cells. On the other hand, the function of aged HSCs did not recover in the young bone marrow niche. The epigenome (DNA methylation) of aged HSCs did not change significantly even in the young bone marrow niche, and DNA methylation profiles were found to be a better index than the gene expression pattern of aged HSCs. ....

Atsushi Iwama , Emily Henderson , Institute Of Medical Science , University Of Tokyo , Division Of Stem Cell , Professor Atsushi Iwama , Stem Cell , Molecular Medicine , Medical Science , Experimental Medicine , Lead Scientist , Stem Cells , Bone Marrow , Dna Methylation , Gene Expression , Progenitor Cells , அட்சூஷி இவமா , எமிலி ஹென்டர்சன் , நிறுவனம் ஆஃப் மருத்துவ அறிவியல் , பல்கலைக்கழகம் ஆஃப் டோக்கியோ , பிரிவு ஆஃப் தண்டு செல் , ப்ரொஃபெஸர் அட்சூஷி இவமா , தண்டு செல் , மூலக்கூறு மருந்து , மருத்துவ அறிவியல் , சோதனை மருந்து ,