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Breakthrough discovery could lead to new treatments for brain metastases

When cancer that starts in the body metastasizes to the brain, it is almost always lethal, in part because so few treatment options exist. Now a new study by Wistar scientists published in Nature Communications shows that a type of brain cell called astrocytes plays an important role in promoting brain metastasis by recruiting a specific subpopulation of immune cells. ....

Lily Ramsey , Qing Chen , Ronald Caplan Cancer Center , Wistar Institute , Nature Communications , Microenvironment Metastasis Program , Image Credit , Metastasis Program , Brain Metastases , Brain Cell , Breast Cancer ,

Detailed 3D images of the synapse offer precise geometry of interactions between individual cells

Scientists have created one of the most detailed 3D images of the synapse, the important juncture where neurons communicate with each other through an exchange of chemical signals. These nanometer scale models will help scientists better understand and study neurodegenerative diseases such as Huntington's disease and schizophrenia. ....

Danielle Ellis , Jon Sporring , Steve Goldman , Rajmund Mokso , Carlos Benitez Villanueva , Hans Stephensen , Lundbeck Foundation , Study Co , University Of Copenhagen , Lund University , University Of Rochester , Novo Nordisk Foundation , Research Associate Professor , Translational Neuromedicine , Benraiss Phd , Study Co Author , Huntington 39s Disease , Motor Neurons , Neurodegenerative Diseases ,

Biomarker study reveals the effects of astrocyte reactivity in preclinical Alzheimer's disease

Evidence supports a close link between Aβ, astrocyte reactivity, and tau pathology in preclinical AD. ....

United States , Nature Medicine , Alzheimer 39s Disease ,

New research shows astrocytes are key to swaying the pendulum in Alzheimer's disease progression

Why do some people develop Alzheimer's disease while others don't? And, even more puzzlingly, why do many individuals whose brains are chock-full of toxic amyloid aggregates-;a telltale sign of Alzheimer's brain pathology-;never go on to develop Alzheimer's-associated dementias? ....

Bruna Bellaver , Danielle Ellis , Tharick Pascoal , University Of Pittsburgh School Medicine , Pittsburgh School , Lzheimer 39s Disease ,

Glycosylation enzyme plays a crucial role in brain development, study shows

The MGAT5 glycosylation enzyme plays a crucial role in brain development, according to a study by University of California, Irvine researchers, a discovery that may contribute to new therapeutic purposes for neural stem cells. ....

United States , Elisa Flanagan , Megan Craig , University Of California , School Of Medicine , Sue Bill Gross Stem Cell Research Center , Stem Cell Reports , Henry Samueli School , Biomedical Engineering , Bill Gross Stem Cell Research , Neural Stem Cells , Stem Cells ,