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Tislelizumab plus chemotherapy versus placebo plus chemotherapy as first line treatment for advanced gastric or gastro-oesophageal junction adenocarcinoma: RATIONALE-305 randomised, double blind, phase 3 trial

Tislelizumab plus chemotherapy versus placebo plus chemotherapy as first line treatment for advanced gastric or gastro-oesophageal junction adenocarcinoma: RATIONALE-305 randomised, double blind, phase 3 trial
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United statesEteläuomen läiSouth koreaJin wangGenentechf hoffmannAsher biotherapeuticsDaiichi sankyoChipscreen biosciencesBristol myers squibbAshfield medcommsMerck biopharmMerck seronoSamsung bioepisLyell immunopharmaCalithera biosciencesEli lilly

Adagrasib, Cetuximab May Benefit KRASG12c Colorectal Cancer Patients

Adagrasib, Cetuximab May Benefit KRASG12c Colorectal Cancer Patients
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United statesRedx pharmaDaiichi sankyoBristol myers squibb medarexGenentech rocheEli lillyScott kopetzNavire pharmaAstrazeneca medimmuneLutris pharmaUniversity of texas md anderson cancer centerHarbinger healthGilead sciencesGuardant healthAmerican association for cancer researchSerono inc

Adagrasib/Cetuximab Combo Has Activity in KRAS G12C+ Locally Advanced or mCRC

Adagrasib plus cetuximab elicited a 34% objective response rate in patients with previously treated KRAS G12C-mutant advanced colorectal cancer.

United statesSan diegoDaiichi sankyoBristol meyers squibbRedx pharmaEli lillyNavire pharmaGenentech rocheScott kopetzAstrazeneca medimmuneLutris pharmaBristol myers squibb medarexBayer healthDrug administrationIylon precision oncologyGilead sciences

Jay Bradner returns to lead R&D at Amgen—Chutes & Ladders

Jay Bradner returns to lead R&D at Amgen—Chutes & Ladders
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Rahul kakkarAstrazeneca medimmuneStephen hogeChris boshoffAdam rosenthalClay siegallRuben rodriguezJason duncanDavid reeseThomas jensenDon hautVincent oneillMax bayerJohn finnKathy spencer pikeGalvani bioelectronics

Poor oral health could lessen survival from h

An international study has revealed strong associations between oral health and survival among people diagnosed with head and neck cancer. Specifically, better oral health, as evidenced by the number of natural teeth and dental visits prior to the time of diagnosis, was associated with increased survival.

North carolinaUnited statesAdams schoolSao pauloComunidad autonoma de catalunaChapel hillTrevor hackmanAntoniol amelioWendellg yarbroughDouglasr farquharAstrazeneca medimmuneChrisb agalaInvestigacion cientificay tecnologicaAndrewf olshanCarole fakhryKimon divaris