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Understanding how zwitterionic polymers can lead to safer drugs and disease prevention

The formation of aggregates due to protein misfolding and resulting protein instability is associated with several diseases. Previous studies have shown the potential of sulfobetaine polymer, a zwitterionic polymer, to suppress protein aggregation. Now, researchers elucidate the mechanism underlying this process and show ways to optimize protein stabilization using these polymers. Going ahead, future therapies may be able to prevent or reverse diseases like Alzheimer s by building on the unique ability of zwitterionic polymers. ....

Dandan Zhao , Robin Rajan , Kazuaki Matsumura , Tadaomi Furuta , Japan Advanced Institute Of Science , Tokyo Institute Of Technology , Professor Kazuaki Matsumura , Japan Advanced Institute , Assistant Professor Robin Rajan , Assistant Professor Tadaomi Furuta , Tokyo Institute , Cell Reports Physical Science ,

Understanding how zwitterionic polymers can lead to safer drugs and disease prevention

Understanding how zwitterionic polymers can lead to safer drugs and disease prevention
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Robin Rajan , Dandan Zhao , Kazuaki Matsumura , Tadaomi Furuta , Tokyo Institute Of Technology , Japan Advanced Institute Of Science , Professor Kazuaki Matsumura , Japan Advanced Institute , Assistant Professor Robin Rajan , Assistant Professor Tadaomi Furuta , Tokyo Institute , Cell Reports Physical Science ,