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Objective To evaluate whether a structured online supervised group physical and mental health rehabilitation programme can improve health related quality of life compared with usual care in adults with post-covid-19 condition (long covid). Design Pragmatic, multicentre, parallel group, superiority randomised controlled trial. Setting England and Wales, with home based interventions delivered remotely online from a single trial hub. Participants 585 adults (26-86 years) discharged from NHS hospitals at least three months previously after covid-19 and with ongoing physical and/or mental health sequelae (post-covid-19 condition), randomised (1:1.03) to receive the Rehabilitation Exercise and psycholoGical support After covid-19 InfectioN (REGAIN) intervention (n=298) or usual care (n=287). Interventions Best practice usual care was a single online session of advice and support with a trained practitioner. The REGAIN intervention was delivered online over eight weeks and consisted of w

United kingdomScott mcguireDavid mcwilliamsHelen athertonJonathon prosserBeatriz laraMartin underwoodPatrick sawdonFrancesca dentonRachel potterPeter heineEmma padfieldGordon mcgregorNigel edwardsShilpa patelSharisse alleyne