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#VisualAbstract: Diagnosis of Arginine Vasopressin Deficiency using Hypertonic-Saline Stimulation versus Arginine Stimulation

Click here to read this study in NEJM. ©2023 2 Minute Medicine, Inc. All rights reserved. No works may be reproduced without expressed written consent from 2 Minute Medicine, Inc. Inquire about licensing here. No article should be construed as medical advice and is not intended as such by the authors or by 2 Minute Medicine, Inc. ....

Minute Medicine Inc , Arginine Stimulation , Arginine Vasopressin Deficiency , Polyuria Polydipsia Syndrome ,

Hypertonic saline stimulation is superior to arginine for diagnosing AVP deficiency

1. In this prospective cohort study, hypertonic saline-stimulated copeptin was more accurate in diagnosing arginine vasopressin (AVP) deficiency than arginine-stimulated copeptin. 2. The diagnoses made by these tests were compared against final diagnoses by two independent endocrinologists. Evidence Rating Level: 1 (Excellent) Study Rundown: AVP deficiency, formerly known as central diabetes insipidus, is difficult to ....

Minute Medicine Inc , Rating Level , Confidence Interval , Arginine Stimulated Copeptin , Avp Deficiency , Central Diabetes Insipidus , Chronic Disease , Hypertonic Saline , Hypertonic Saline Stimulation ,

Genetic mutation in OXR1 gene linked to brain development issues

Study investigates the effects of a loss-of-function mutation in the OXR1 gene on neurodevelopment and cellular functions in the human brain. The research shows that OXR1 deficiency impairs neural differentiation, increases sensitivity to oxidative stress, and alters histone methylation, impacting brain development and potentially contributing to neurological disorders. ....

Kittyfly Shutterstock , Genome Biology , Oxidation Resistance , Dna Damage , Ene Expression , Oxidative Stress ,

Gene therapy could reverse symptoms of rare, hereditary DOOR syndrome

A lot of research has been done over many decades on diseases that are widespread in large parts of the population, such as cancer and heart disease. As a result, treatment methods have improved enormously thanks to long-term research efforts on diseases that affect many people. ....

Department Of Clinical , Oslo University Hospital , Norwegian University Of Science , Norwegian University , Middle East , Door Syndrome , Gene Therapy , Heart Disease , Skin Cells ,