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Identifying the initial steps in colorectal cancer formation

Identifying the initial steps in colorectal cancer formation
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Researchers identify the initial steps in colorectal cancer formation

Research led by Weill Cornell Medicine provides new evidence that most colorectal cancers begin with the loss of intestinal stem cells, even before cancer-causing genetic alterations appear. The results, published on May 29 in Developmental Cell, overturn the prevailing theory for colorectal tumor initiation and suggest new ways to diagnose the disease before it has a chance to become established.

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