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Researchers propose 'RNAkine' nomenclature for naming extracellular ncRNAs

Researchers propose 'RNAkine' nomenclature for naming extracellular ncRNAs
phys.org - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from phys.org Daily Mail and Mail on Sunday newspapers.

Jing Li , Chen Yu Zhang , Chen Yu Zhang Nanjing University , Jing Li Nanjing University , Antonio Vidal Puig University Of Cambridge , Nanjing University , Antonio Vidal Puig ,

Obesity doesn't always mean ill health. Here's what scientists are learning | Science

Obesity doesn't always mean ill health. Here's what scientists are learning | Science
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United Kingdom , Chapel Hill , United States , Samuel Klein , Ruth Loos , Antonio Vidal Puig , Cynthia Bulik , Bernard Zinman , Philipp Scherer , David Allison , Sadaf Farooqi , Matthias Schulze , Indiana University , University Of California , Us Centers For Disease , University Of Copenhagen , German Institute Of Human Nutrition , Karolinska Institute , National Cancer Institute , University Of North Carolina , School Of Public Health , University Of Cambridge , University Of Toronto , University Of Texas Southwestern Medical Center , Nurse Health Study , Texas Southwestern Medical ,

Obesity doesn't always mean ill health. Here's what scientists are learning | Science

Obesity doesn't always mean ill health. Here's what scientists are learning | Science
sciencemag.org - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from sciencemag.org Daily Mail and Mail on Sunday newspapers.

United States , Chapel Hill , United Kingdom , Samuel Klein , Ruth Loos , Antonio Vidal Puig , Cynthia Bulik , Bernard Zinman , Philipp Scherer , Jennifer Couzin Frankel , David Allison , Sadaf Farooqi , Carrie Ann Rainey , Matthias Schulze , Indiana University , University Of California , Us Centers For Disease , University Of Copenhagen , German Institute Of Human Nutrition , Karolinska Institute , National Cancer Institute , University Of North Carolina , School Of Public Health , University Of Cambridge , University Of Toronto , University Of Texas Southwestern Medical Center ,

Beyond secretion of insulin,the novel function of β cell in regulating glucose homeostasis

In a new study published in
Journal of Extracellular Vesicles, Chen-Yu Zhang s group and Antonio Vidal-Puig s group at University of Cambridge report that pancreatic β cells secrete miR-29 family members (miR-29a, miR-29b and miR-29c) in response to high levels of free fatty acids (FFAs). These β cell-derived miR-29s are delivered to the liver, promoting insulin resistance and enhancing hepatic glucose output.
Over 100 years after insulin was discovered, it was believed that pancreatic β cells only secreted a single hormone insulin. Pancreatic β cell-derived insulin regulates glucose homeostasis by binding with the insulin receptors located in the liver, skeletal muscle, adipose tissues and other peripheral organs. The discovery of insulin and its receptor was essential to understand the mechanisms controlling glucose homeostasis and the pathogenesis of type 2 diabetes defined by defective insulin secretion, signal transduction and insulin resistance. However, gluco ....

Jing Li , United Kingdom , Xiang Zhang , Junfeng Zhang , Antonio Vidal Puig , Dameng Li , Eunyoung Lee , Shibei Wang , Chen Yu Zhang , Xiaohong Jiang , Yuchen Liu , Xin Dai , Mingliang Zhang , Yujing Zhang , Weiping Jia , Century Excellent Talents In University , National Basic Research Program Of China , Institute Of Life Sciences , Key Laboratory Of Pharmaceutical Biotechnology , National Science Fund For Distinguished Young Scholars , University Of Cambridge , Program No , Drum Tower Hospital Center , Research Funds For The Central Universities , Natural Science Foundation Of Jiangsu Province , Ministry Of Education ,

Pancreatic β cell-derived exosomal miR-29 family enhances hepatic glucose output

In a new study published in
Journal of Extracellular Vesicles, Chen-Yu Zhang s group at Nanjing University, School of Life Sciences, and Antonio Vidal-Puig s group at University of Cambridge report that pancreatic β cells secrete miR-29 family members (miR-29s) via exosomes in response to high levels of free fatty acids (FFAs). Theses β cell-derived exosomal miR-29s regulate glucose homeostasis through their manipulations on glucose output in liver.
Previously, Chen-Yu Zhang s group identified extracellular miRNA as a new form of cell-to-cell communication. They are among the first that reported the selective secretion of miRNAs under different physiological or pathological states; also, the uptake and function of secreted miRNAs in recipient cells. In the past decade, intensive studies have revealed the role of extracellular miRNAs in a range of biological processes. Thus, as a newly-emerged secretory factor, more insightful studies are needed to further reveal its re ....

Jing Li , United Kingdom , Xiang Zhang , Junfeng Zhang , Antonio Vidal Puig , Dameng Li , Eunyoung Lee , Shibei Wang , Chen Yu Zhang , Xiaohong Jiang , Yuchen Liu , Xin Dai , Mingliang Zhang , Yujing Zhang , Weiping Jia , Century Excellent Talents In University , National Basic Research Program Of China , Institute Of Life Sciences , Key Laboratory Of Pharmaceutical Biotechnology , National Science Fund For Distinguished Young Scholars , University Of Cambridge , Program No , Drum Tower Hospital Center , Research Funds For The Central Universities , Natural Science Foundation Of Jiangsu Province , Ministry Of Education ,