could dramatically increase the antibody by a boost at the third boost months later. and if you looked at that the increase was really rather substantial. but again not to downplay the ultimate potential importance of t-cells. but if you look at the relationship between antibody titer and vaccine it looks pretty good. next question, please? thank you for taking my question. it sounds like effectiveness starts wane sooner than eight months. if fly is not an issue, can you walk us through the science of how you landed on eight months? why don t we start with you, dr. murphy, and then if anyone