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"Nothing comes without a downside. These molecules do produce significant nausea and vomiting in some people — to the extent that they have to discontinue the medication. Some may develop diarrhoea, some may have severe constipation. Others may not like the way they lose weight—they may feel very shrunken or their face may seem very thinned out. Thats another sort of downside," says Dr Ambrish Mithal, chairman, endocrinology & diabetes, Max Healthcare, Delhi.