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Nasal anti-CD3 antibody improves Alzheimer's disease in mice

Alzheimer’s disease (AD) has a new candidate for its treatment. Nasal anti-CD3 monoclonal antibody (MAb) reduced microglia activation in the brain of mice without its effect being dependent on the β-amyloid (Aβ) deposits characteristic of this neurodegenerative disorder. “We have done many basic studies in the laboratory on microglia. Microglia activation occurs in many neurologic diseases. One of them is multiple sclerosis (MS). And it also occurs in AD,” senior author Howard Weiner told BioWorld. ....

Howard Weiner , Alzheimers Disease , Brigham And Womens Hospital , Nasal Delivery , Anti Cd3 Antibodies ,