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Venous thromboembolism with use of hormonal contraception and non-steroidal anti-inflammatory drugs: nationwide cohort study

Objective To study the influence of concomitant use of hormonal contraception and non-steroidal anti-inflammatory drugs (NSAIDs) on the risk of venous thromboembolism.

Design Nationwide cohort study.

Setting Denmark through national registries.

Participants All 15-49 year old women living in Denmark between 1996 and 2017 with no medical history of any venous or arterial thrombotic event, cancer, thrombophilia, hysterectomy, bilateral oophorectomy, sterilisation, or infertility treatment (n=2 029 065).

Main outcome measure A first time discharge diagnosis of lower limb deep venous thrombosis or pulmonary embolism.

Results Among 2.0 million women followed for 21.0 million person years, 8710 venous thromboembolic events occurred. Compared with non-use of NSAIDs, use of NSAIDs was associated with an adjusted incidence rate ratio of venous thromboembolism of 7.2 (95% confidence interval 6.0 to 8.5) in women not using hormonal contraception, 11.0 (9.6 t ....

Maurizio Sessa , Anne Pernille Toft Petersen , Annalisa Capuano , Oejvind Lidegaard , Charlotte Wessel Skovlund , Christian Torp Pedersen , Francesco Rossi , Thomas Alexander Gerds , Annamaria Mascolo , Amani Meaidi , Regitze Skals , Lina Steinrud Morch , National Health Service , Danish Heart Foundation , Drug Administration , Nuclear Medicine , National Registry Of Medicinal Product Statistics , European Medicine Agency , Danish Cancer Society Scientific Committee , National Registry Of Causes Death , National Patient Registry , Novo Nordisk , Pernille Toft Petersen , Alexander Gerds , Wessel Skovlund , Steinrud Morch ,

Postmarketing active surveillance of myocarditis and pericarditis following vaccination with COVID-19 mRNA vaccines in persons aged 12 to 39 years in Italy: A multi-database, self-controlled case series study

Marco Massari and colleagues investigate the association between myocarditis/pericarditis and COVID-19 mRNA vaccines in individuals aged 12-39 years in Italy. ....

United States , Friuli Venezia Giulia , United Kingdom , Brighton And Hove , Nazanin Morgheiseh Emilia Romagna , Emanuela Bovo , Olivia Leoni , Cristina Morciano , Jamesg Beeson , Eli Lilly , Marco Tuccori , Pasquale Marchione , Silvio Tafuri , Pasquale Stefanizzi , Ilaria Ippoliti , Carlo Villanacci , Valeria Desiderio , Patrizia Popoli , Matteo Spuri , Michele Ercolanoni , Maria Balducci , Valentina Borsi Toscana , Daiichi Sankyo , Lorella Lombardozzi , Sara Samez , Massimo Fabiani ,