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You Are Likely To Live Longer Than You Think

The report from the trenches of the first day of the 10th Aging Research for Drug Discovery, Copenhagen, August 29, 2023 ....

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Vaccine Responses in Older Adults Boosted by Drug That Helps Immune Cells Self-Clean

Vaccine Responses in Older Adults Boosted by Drug That Helps Immune Cells Self-Clean
December 16, 2020
One needs to look no further than the COVID-19 pandemic to highlight the point that older adults are in the high-risk category for infectious diseases. With vaccines starting to be rolled out in the United States, so too is hope for the protection of this vulnerable group. While most vaccines are less efficacious in older adults, little is known about the molecular mechanisms that underpin this.
A new study shows that autophagy, a process critical for the maintenance of immune memory in mice, is specifically induced in vaccine-induced antigen-specific CD8+ T cells in healthy human volunteers. In addition, a drug that boosts the removal of cellular debris in immune cells, spermidine, may increase the protective effects of vaccines in older adults. The results may lead to new approaches to protect older individuals from viruses such as the one causing the current COVID- ....

United States , Anna Katharina Simon , Ghada Alsaleh , University Of Oxford , Kennedy Institute Of Rheumatology , Kennedy Institute , ஒன்றுபட்டது மாநிலங்களில் , அண்ணா காதரின சிமோன் , பல்கலைக்கழகம் ஆஃப் ஆக்ஸ்ஃபர்ட் , கெந்நெடீ நிறுவனம் ஆஃப் வாத நோய் , கெந்நெடீ நிறுவனம் ,

Drug may boost vaccine responses in older adults

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A drug that boosts the removal of cellular debris in immune cells may increase the protective effects of vaccines in older adults, a study published today in
eLife shows.
The results may lead to new approaches to protect older individuals from viruses such as the one causing the current COVID-19 pandemic and influenza.
Older adults are at high risk of being severely affected by infectious diseases, but unfortunately most vaccines in this age group are less efficient than in younger adults, explains lead author Ghada Alsaleh, a postdoctoral researcher at the Kennedy Institute of Rheumatology, University of Oxford, UK. ....

United Kingdom , Josie Eade , Emily Packer , Ghada Alsaleh , Anna Katharina Simon , University Of Oxford , Alice Wallenberg Foundation , Kennedy Institute Of Rheumatology , Nuffield Department Of Orthopaedics , Musculoskeletal Sciences , Max Planck Society , Howard Hughes Medical Institute , Kennedy Institute , Media Relations Manager , Acting Communications Manager , ஒன்றுபட்டது கிஂக்டம் , ஜோசி எாடெ , எமிலி ப்யாகர் , அண்ணா காதரின சிமோன் , பல்கலைக்கழகம் ஆஃப் ஆக்ஸ்ஃபர்ட் , ஆலிஸ் வாலன்பெர்க் அடித்தளம் , கெந்நெடீ நிறுவனம் ஆஃப் வாத நோய் , நுஃபையீல்ட் துறை ஆஃப் எலும்பியல் , தசைக்கூட்டு அறிவியல் , ஹோவர்ட் ஹக்ஸ் மருத்துவ நிறுவனம் , கெந்நெடீ நிறுவனம் ,

Drug may increase vaccine protection in older adults

Drug may increase vaccine protection in older adults
A drug that boosts the removal of cellular debris in immune cells may increase the protective effects of vaccines in older adults, a study published today in
eLife shows.
The results may lead to new approaches to protect older individuals from viruses such as the one causing the current COVID-19 pandemic and influenza.
Older adults are at high risk of being severely affected by infectious diseases, but unfortunately most vaccines in this age group are less efficient than in younger adults.
Ghada Alsaleh, Lead Author, Postdoctoral Researcher, Kennedy Institute of Rheumatology, University of Oxford, UK ....

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