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Brain metastases are among the most severe complications of systemic breast cancer, and overexpression of the human epidermal growth factor receptor 2 (HER2) in breast cancer cells increases the incidence of brain metastases in patients. In this study, we engineered the human-derived, tumor cell tropic neural stem cells LM-NSC008 (LM008) to continuously secrete antibodies against HER2. These anti-HER2 antibodies impaired tumor cell proliferation by inhibiting the PI3K-Akt signaling pathway in HER2+ breast cancer cells in vitro. Importantly, our results demonstrate that the therapeutic combinatorial regimen consisting of LM-NSC008 anti-HER2 antibody-secreting cells and the HER2 kinase inhibitor tucatinib provide therapeutic benefit and prolong survival in preclinical models of HER2+ breast cancer brain metastases. ....
greg: he took a [interesting] thank you. at sea and then to the list of things joe rogan now owns. he admitted to joe rogan that it was wrong for the network, including don lemon and jim acosta, the claim rogan took this as a treatment that he does deposit of that by resident had been several drugs including our vermont and bid that drug is fda approved for use in humans and the formula for animal use is much more concentrated. that is not what rogan was taken, but cnn didn t care and said rogan was taking horse pills britt on wednesday, he called them out. you are lying to your network. calling it a horse the worm ....