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Intranasal vaccination: A potent one-time solution for comprehensive COVID-19 immunity

A single-dose intranasal vaccine effectively induces robust immune responses. ....

Drug Administration , Texas Medical Branch , Institutional Animal Care , Use Committee , Animal Biosafety Level , Enzyme Linked Immunosorbent Assay , Binding Domain , Counter Pro System , Interferon Gamma , Covid 19 , B Cell , Global Health , Ars Cov 2 , Evere Acute Respiratory , Evere Acute Respiratory Syndrome , Weight Loss ,

Pfizer, Project Veritas, and biosecurity

Pfizer, Project Veritas, and biosecurity
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United States , Centers For Disease , Agent Program , Boston University National Emerging Infectious Diseases Laboratory , University Of Texas Southwestern , National Institutes Of Health , Research Development Strategic Operations , National Science Advisory Board For Biosecurity , Project Veritas , Jordan Walker , Development Strategic Operations , Pfizer Exploring , For New , Texas Southwestern , Select Agent Program , Biosafety Level , Animal Biosafety Level , National Science Advisory Board , Boston University , National Emerging Infectious Diseases Laboratory , Disease Control , National Institutes ,

Single-dose therapeutic interfering particle lowers SARS-CoV-2 pathogenesis and shedding among hamsters

Researchers reported that a single-dose therapeutic interfering particle (TIP) lowers SARS-CoV-2 pathogenesis and shedding among hamsters. ....

Johannes Menge Shutterstock , Scripps Research Institute , Gladstone Institutes , Biosafety Level , Animal Biosafety Level , Coronavirus Disease Covid 19 , Ars Cov 2 , Covid 19 , Respiratory Virus , Ibonucleic Acid , Evere Acute Respiratory , Evere Acute Respiratory Syndrome ,

Insights into the pathogenesis of the previous and circulating SARS-CoV-2 variants in mice

A recent article presented the diverse pathogenesis of SARS-CoV-2 variants of concern in a humanized mouse model. ....

Alpha Vocs , Beta Vocs , Animal Biosafety Level , Coronavirus Disease Covid 19 , Ars Cov 2 , Ngiotensin Converting Enzyme 2 , Covid 19 , Ene Expression , Ouse Model , Evere Acute Respiratory , Evere Acute Respiratory Syndrome , Weight Loss ,

Middle East respiratory syndrome coronavirus vaccine based on a propagation-defective RNA replicon elicited sterilizing immunity in mice

Coronaviruses (CoVs) have the largest genome among RNA viruses and a proofreading exoribonuclease (nsp14) responsible for high-fidelity RNA synthesis. These properties make CoVs very attractive for the establishment of vaccine platforms or viral vectors since they can stably store large amounts of information without genome integration. Using Middle East respiratory syndrome coronavirus (MERS-CoV) as a model, a propagation-deficient RNA replicon was generated by removing the envelope (E) gene (essential for viral morphogenesis and involved in virulence) and accessory genes 3, 4a, 4b, and 5 (responsible for antagonism of the innate immune response): MERS-CoV-Δ[3,4a,4b,5,E]. This replicon is strongly attenuated and elicits sterilizing protection after a single immunization, making it a promising vaccine candidate and an interesting platform for vector-based vaccine development. ....

Jouy En Josas , France General , Baden Wüberg , Noord Holland , Universiteit Van , Severo Ochoa , Paul Mccray , Environmental Council Of Madrid , University Of Iowa , Miltenyi Biotec Inc , International European Union Guideline , Spanish National Royal Decree , Histology Service , Electron Microscopy Service Of Centro De Biolog , Mac Graphpad Software , California Institute Of Technology , Ethical Committee Of Centro De Investigaci , Spanish National Law , University Of Heidelberg , Middle East , West Nile , Environmental Council , Ethical Committee , Centro De Investigaci , Sanidad Animal , Instituto Nacional De Investigaci ,