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Chip-scale microscope specified for high-throughput fluorescence imaging

Imec receives ERC grant to develop novel fluorescence microscope-on-chip; and new EC-funded scope project targets “superbugs”.

Tracking down the tiniest of forces: How T cells detect invaders

 E-Mail IMAGE: The T cell (yellow) touches the antigen-presenting cell. Tiny forces are applied on the surface, eventually the connection breaks. view more  Credit: TU Wien / MedUni Wien T-cells play a central role in our immune system: by means of their so-called T-cell receptors (TCR) they make out dangerous invaders or cancer cells in the body and then trigger an immune reaction. On a molecular level, this recognition process is still not sufficiently understood. Intriguing observations have now been made by an interdisciplinary Viennese team of immunologists, biochemists and biophysicists. In a joint project funded by the Vienna Science and Technology Fund and the FWF, they investigated which mechanical processes take place when an antigen is recognized: As T cells move their TCRs pull on the antigen with a tiny force - about five pico-newtons (5 x 10-12 or 0.0000000005 newtons). This is not only sufficient to break the bonds between the TCRs and the antigen, it a

How acidic are atoms?

 E-Mail IMAGE: Using the modified tip of an atomic force microscope, individual atoms in the surface can be probed. view more  Credit: TU Wien The degree of acidity or alkalinity of a substance is crucial for its chemical behavior. The decisive factor is the so-called proton affinity, which indicates how easily an entity accepts or releases a single proton. While it is easy to measure this for molecules, it has not been possible for surfaces. This is important because atoms on surfaces have very different proton affinities, depending on where they sit. Researchers at TU Wien have now succeeded in making this important physical quantity experimentally accessible for the first time: Using a specially modified atomic force microscope, it is possible to study the proton affinity of individual atoms. This should help to analyze catalysts on an atomic scale. The results have been published in the scientific journal

A new state of light

 E-Mail IMAGE: On the right is a microscope objective used to observe and analyze the light emerging from the resonator. view more  Credit: © Gregor Hübl/Uni Bonn A single super photon made up of many thousands of individual light particles: About ten years ago, researchers at the University of Bonn produced such an extreme aggregate state for the first time and presented a completely new light source. The state is called optical Bose-Einstein condensate and has captivated many physicists ever since, because this exotic world of light particles is home to its very own physical phenomena. Researchers led by Prof. Dr. Martin Weitz, who discovered the super photon, and theoretical physicist Prof. Dr. Johann Kroha have returned from their latest expedition into the quantum world with a very special observation. They report of a new, previously unknown phase transition in the optical Bose-Einstein condensate. This is a so-called overdamped phase. The results may in the

A speed limit also applies in the quantum world | EurekAlert! Science News