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Unlocking RNA functionality: A redox-responsive approach

Chemists have developed a strategy using disulfide-containing small molecules to facilitate the reversible control and delivery of ribonucleic acid (RNA). A research team has developed a method that takes advantage of a chemical process called post-synthetic RNA acylation chemistry, and combined it with dynamic disulfide exchange reaction for RNA delivery and reversible control. This method provides a way to mask the RNA molecule, and researchers can potentially regulate its activity and delivery until it reaches its target site within the cell. ....

Angewandte Chemie International Edition , Department Of Chemistry , Assistant Professor , Prof Zhu , Asst Prof ,

Nonlinear Photochromic Properties in a Perylene-Substituted Rhodamine Spirolactam

Researchers develop a novel design approach to achieve nonlinear photochromism using easy-to-synthesize rhodamine spirolactam derivatives Nonlinear photochromic compounds that utilize low-energy light have received significant attention. They result in enhanced contrast and spatial resolution in photochromic reactions and allow multiple photofunctions in single molecules. However, they require complex molecular design, which limits their wide applicability. Now, researchers have achieved nonlinear photochromism using low-energy light in an easily synthesized perylene-substituted rhodamine spirolactam derivative, offering a novel design approach for simpler photofunctional materials. ....

Yoichi Kobayashi , Department Of Applied Chemistry , College Of Life Sciences At Ritsumeikan University , Angewandte Chemie International Edition On , Professor Yoichi Kobayashi , Applied Chemistry , Life Sciences , Ritsumeikan University , Angewandte Chemie International Edition ,

Rhodamine Spirolactam Shows Nonlinear Photochromic Traits

Rhodamine Spirolactam Shows Nonlinear Photochromic Traits
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Yoichi Kobayashi , Department Of Applied Chemistry , Angewandte Chemie International Edition On , College Of Life Sciences At Ritsumeikan University , Professor Yoichi Kobayashi , Applied Chemistry , Life Sciences , Ritsumeikan University , Angewandte Chemie International Edition ,